4-[[Benzyl(cyclohexylcarbamoyl)amino]methyl]piperidine-1-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-[[Benzyl(cyclohexylcarbamoyl)amino]methyl]piperidine-1-carboxylic acid
• 英文别名: 4-[[benzyl(cyclohexylcarbamoyl)amino]methyl]piperidine-1-carboxylic acid
• 化学式: C₂₁H₃₁N₃O₃
• 分子量: 373.5
• InChiKey: WTLUAOIZDVNJSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  72.9
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• BENZYL UREA DERIVATIVES FOR ACTIVATING TGF-BETA SIGNALING
  申请人：THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

  公开号：US20160039756A1

  公开（公告）日：2016-02-11

  Compositions and methods for treatment and prevention of disorders and conditions characterized by reduced TGF-B signaling are described. In particular, the compositions and methods are useful for reducing or eliminating the pathologies associated with Alzheimer's disease. The compositions include urea derivatives containing a piperidine, piperidinium, or a piperidin-4-yl methyl; cycloalkyl, aryl, and fluorobenzyl moieties.

  本文描述了用于治疗和预防由于TGF-B信号降低而特征化的疾病和病状的组合物和方法。特别地，这些组合物和方法对于减少或消除与阿尔茨海默病相关的病理病变非常有用。这些组合物包括含有哌啶，哌啶盐酸盐或哌啶-4-基甲基，环烷基，芳香基和氟苯甲基的脲衍生物。
• US9796674B2
  申请人：——

  公开号：US9796674B2

  公开（公告）日：2017-10-24
• [EN] BENZYL UREA DERIVATIVES FOR ACTIVATING TGF-BETA SIGNALING<br/>[FR] DÉRIVÉS DE BENZYLURÉE POUR L'ACTIVATION DE LA SIGNALISATION DE TGF-BÊTA
  申请人：UNIV LELAND STANFORD JUNIOR

  公开号：WO2014152869A2

  公开（公告）日：2014-09-25

  Compositions and methods for treatment and prevention of disorders and conditions characterized by reduced TGF-β signaling are described. In particular, the compositions and methods are useful for reducing or eliminating the pathologies associated with Alzheimer's disease.