4-[2-(Trifluoromethyl)phenyl]piperidine-1-carbaldehyde

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-[2-(Trifluoromethyl)phenyl]piperidine-1-carbaldehyde
• 英文别名: 4-[2-(trifluoromethyl)phenyl]piperidine-1-carbaldehyde
• 化学式: C₁₃H₁₄F₃NO
• 分子量: 257.25
• InChiKey: TZHGVDGEYLSUAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE<br/>[FR] 4-PHÉNYLPIPÉRIDINES, LEUR PRÉPARATION ET LEUR UTILISATION
  申请人：UNIV COLUMBIA

  公开号：WO2014152013A1

  公开（公告）日：2014-09-25

  The present invention provides a compound having the structure: (structurally represented) wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl; R6 is H, OH, or halogen; B is a substituted or unsubstituted heterobicycle, pyridazine, pyrazole, pyrazine, thiadiazole, or triazole, wherein the heterobicycle is other than chloro substituted indole; and the pyrazole, when substituted, is substituted with other than trifluoromethyl, or a pharmaceutically acceptable salt theref.

  本发明提供一种具有以下结构的化合物：(结构表示)其中R1、R2、R3、R4和R5分别独立地为H、卤素、CF3或C1-C4烷基；R6为H、OH或卤素；B为取代或未取代的杂环、吡啶并[1,2-a]嘧啶、吡唑并[1,2-a]嘧啶、噻二唑或三唑，其中该杂环不是氯取代的吲哚；当取代时，吡唑除三氟甲基外还取代其他官能团，或其药学上可接受的盐。
• 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE
  申请人：PETRUKHIN Konstantin

  公开号：US20160046648A1

  公开（公告）日：2016-02-18

  The present invention provides a compound having the structure: (structurally represented) wherein R 1 , R 2 , R 3 , R 4 , and R 5 are each independently H, halogen, CF 3 or C 1 -C 4 alkyl; R 6 is H, OH, or halogen; B is a substituted or unsubstituted heterobicycle, pyridazine, pyrazole, pyrazine, thiadiazole, or triazole, wherein the heterobicycle is other than chloro substituted indole; and the pyrazole, when substituted, is substituted with other than trifluoromethyl, or a pharmaceutically acceptable salt thereof.

  本发明提供了一种化合物，其结构为：（结构式表示），其中R1、R2、R3、R4和R5各自独立地为H、卤素、CF3或C1-C4烷基；R6为H、OH或卤素；B为取代或未取代杂环、吡嗪、吡唑、吡嗪、噻二唑或三唑，其中杂环不是氯取代的吲哚；当吡唑取代时，取代基不是三氟甲基，或其药学上可接受的盐。
• 4-phenylpiperidines, their preparation and use
  申请人：The Trustees of Columbia University in the City of New York

  公开号：US10273243B2

  公开（公告）日：2019-04-30

  The present invention provides a compound having the structure: (structurally represented) wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl; R6 is H, OH, or halogen; B is a substituted or unsubstituted heterobicycle, pyridazine, pyrazole, pyrazine, thiadiazole, or triazole, wherein the heterobicycle is other than chloro substituted indole; and the pyrazole, when substituted, is substituted with other than trifluoromethyl, or a pharmaceutically acceptable salt thereof.

  本发明提供了一种具有以下结构的化合物：(结构表示），其中 R1、R2、R3、R4 和 R5 各自独立地为 H、卤素、CF3 或 C1-C4 烷基；R6 为 H、OH 或卤素；B 为取代或未取代的杂环、哒嗪、吡唑、吡嗪、噻二唑或三唑，其中杂环为氯取代的吲哚以外的杂环；吡唑取代时为三氟甲基以外的取代基，或其药学上可接受的盐。
• METHODS OF TREATING METABOLIC DISEASES WITH FUSED BICYCLIC PYRAZOLES
  申请人：Belite Bio, Inc

  公开号：EP3638238A1

  公开（公告）日：2020-04-22
• [EN] METHODS OF TREATING METABOLIC DISEASES WITH FUSED BICYCLIC PYRAZOLES<br/>[FR] PROCÉDÉS DE TRAITEMENT DE MALADIES MÉTABOLIQUES AVEC DES PYRAZOLES BICYCLIQUES FUSIONNÉS
  申请人：BELITE BIO INC

  公开号：WO2018232154A1

  公开（公告）日：2018-12-20

  Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for the treatment of retinal binding protein (RBP4) related diseases, such as obesity and the like.