(4S,12R,13R,16S,18S,19E,21E,23E,25S,27R)-12,18-dihydroxy-13,19,25,27-tetramethyl-2,34-dioxa-9-azatetracyclo[27.2.2.112,16.04,9]tetratriaconta-19,21,23-triene-3,10,11,28-tetrone

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯内酰胺
• 英文名称: (4S,12R,13R,16S,18S,19E,21E,23E,25S,27R)-12,18-dihydroxy-13,19,25,27-tetramethyl-2,34-dioxa-9-azatetracyclo[27.2.2.112,16.04,9]tetratriaconta-19,21,23-triene-3,10,11,28-tetrone
• 化学式: C₃₅H₅₁NO₈
• 分子量: 613.8
• InChiKey: AMZISLCFIPOGMV-YFTMKHHPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  44
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  130
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• RAPAMYCIN ANALOGUES AND THEIR PHARMACEUTICAL USE
  申请人：Isomerase Therapeutics Limited

  公开号：US20160176893A1

  公开（公告）日：2016-06-23

  Novel rapamycin analogues and methods for their production with FKBP and/or MIP inhibitory activity with reduced mTOR inhibitory activity with therapeutic potential e.g. as bacterial virulence inhibitors.

  小说雷帕霉素类似物及其生产方法，具有FKBP和/或MIP抑制活性，同时减少mTOR抑制活性，具有治疗潜力，例如作为细菌毒力抑制剂。
• METHODS FOR INCREASING MOLECULAR DIVERSITY OF POLYKETIDES AND NON-RIBOSOMAL PROTEINS
  申请人：ISOMERASE THERAPEUTICS LIMITED

  公开号：US20170101659A1

  公开（公告）日：2017-04-13

  A method for increasing the molecular diversity of polyketides and non-ribsomomal peptides by using recombination to efficiently increase or decrease the number of modules in the polyketide synthase or non-ribosomal peptide synthetase encoding said polyketide or peptide.
• US9505773B2
  申请人：——

  公开号：US9505773B2

  公开（公告）日：2016-11-29
• US9976165B2
  申请人：——

  公开号：US9976165B2

  公开（公告）日：2018-05-22
• [EN] NOVEL COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS
  申请人：ISOMERASE THERAPEUTICS LTD

  公开号：WO2015004455A2

  公开（公告）日：2015-01-15

  Novel rapamycin analogues and methods for their production with FKBP and/or MIP inhibitory activity with reduced mTOR inhibitory activity with therapeutic potential e.g. as bacterial virulence inhibitors.