5-methyl-thiophene-2-carboxylic acid thiazol-2-ylamide | 790725-27-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 5-methyl-thiophene-2-carboxylic acid thiazol-2-ylamide
• 英文别名: 5-methyl-N-(1,3-thiazol-2-yl)thiophene-2-carboxamide
• CAS: 790725-27-8
• 化学式: C₉H₈N₂OS₂
• mdl: MFCD06359913
• 分子量: 224.307
• InChiKey: LJHKKHFSZGKOKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.111
• 拓扑面积：
  98.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• NOVEL 3,5-DISUBSTITUTED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUTED -3H-[1,2,3]TRIAZOLO[4,5-B] PYRIDINE COMPOUNDS AS MODULATORS OF C-MET PROTEIN, ETC
  申请人：Rhizen Pharmaceuticals SA

  公开号：US20150057309A1

  公开（公告）日：2015-02-26

  The present invention provides compounds useful as c-Met protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of c-Met kinase mediated disease or disorders with them.

  本发明提供了作为c-Met蛋白激酶调节剂有用的化合物，以及制备它们的方法，含有它们的药物组合物，以及使用它们进行治疗、预防和/或改善c-Met激酶介导的疾病或疾病的方法。
• NOVEL 3,5-DISUBSTITUTED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUTED -3H-[1,2,3]TRIAZOLO[4,5-B] PYRIDINE COMPOUNDS AS MODULATORS OF PROTEIN KINASES
  申请人：MUTHUPPALANIAPPAN Meyyappan

  公开号：US20110281865A1

  公开（公告）日：2011-11-17

  The present invention provides, inter alia, compounds of formula I as protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.

  本发明提供了一种公式I的化合物作为蛋白激酶调节剂，以及它们的制备方法、含有它们的药物组合物，以及利用它们治疗、预防和/或改善激酶介导的疾病或紊乱的方法。
• [EN] GLUCOKINASE ACTIVATORS<br/>[FR] ACTIVATEURS DE LA GLUCOKINASE
  申请人：MERCK PATENT GMBH

  公开号：WO2009106203A1

  公开（公告）日：2009-09-03

  Novel compounds of the Formula (I) in which R1, R2, R3, and R4 have the meanings indicated in Claim 1, are activators of glucokinase and can be used for the prevention and/or treatment of Diabetes Typ 1 and 2, obesity, neuropathy and/or nephropathy.

  Formula (I)中R1、R2、R3和R4具有权利要求1中所指示的含义的新化合物是葡萄糖激酶的激活剂，可用于预防和/或治疗糖尿病1型和2型、肥胖症、神经病和/或肾病。
• NOVEL 3,5-DISUBSTITUTED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5-DISUBSTITUTED -3H-[1,2,3]TRIAZOLO[4,5-B] PYRIDINE COMPOUNDS AS MODULATORS OF PROTEIN KINASES
  申请人：Rhizen Pharmaceuticals SA

  公开号：US20130261116A1

  公开（公告）日：2013-10-03

  The present invention provides, inter alia, compounds of formula I as protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.

  本发明提供了一些公式I化合物作为蛋白激酶调节剂，它们的制备方法，包含它们的制药组合物，以及使用它们进行激酶介导的疾病或障碍的治疗、预防和/或改善的方法。
• Glucokinase Activators
  申请人：Burgdorf Lars

  公开号：US20100331338A1

  公开（公告）日：2010-12-30

  Novel compounds of the Formula (I) in which R 1 , R 2 , R 3 , and R 4 have the meanings indicated in Claim 1, are activators of glucokinase and can be used for the prevention and/or treatment of Diabetes Type 1 and 2, obesity, neuropathy and/or nephropathy.

  公式（I）中的新化合物，其中R1、R2、R3和R4具有声明1中指示的含义，是葡萄糖激酶的活化剂，可用于预防和/或治疗1型和2型糖尿病、肥胖症、神经病和/或肾病。