N-(3-ethoxypropyl)thiophene-2-carboxamide | 510740-11-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: N-(3-ethoxypropyl)thiophene-2-carboxamide
• CAS: 510740-11-1
• 化学式: C₁₀H₁₅NO₂S
• mdl: MFCD03446758
• 分子量: 213.301
• InChiKey: JLFADXKQMZIROK-UHFFFAOYSA-N

物化性质

• 沸点：
  391.9±22.0 °C(Predicted)
• 密度：
  1.112±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  66.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氰基噻吩 、 3-乙氧基丙胺 在 水 作用下， 反应 17.0h， 以95%的产率得到N-(3-ethoxypropyl)thiophene-2-carboxamide
  参考文献：
  名称：

  Green and Selective Synthesis ofN-Substituted Amides using Water Soluble Porphyrazinato Copper(II) Catalyst

  摘要：

  N, N',N '', N '''-Tetramethyl tetra-2,3-pyridinoporphyrazinato copper(II) methyl sulfate ([Cu(2,3-tmtppa)](MeSO4)(4)) efficiently catalyzed the direct conversion of nitriles to N-substituted amides. The one pot selective synthesis of the N-substituted amides from nitriles and primary amines was performed in refluxing H2O. The catalyst was recovered and reused at least four times, maintaining its efficiency.

  DOI：

  10.5935/0103-5053.20130115

文献信息

• Green and Selective Synthesis of<i>N</i>-Substituted Amides using Water Soluble Porphyrazinato Copper(II) Catalyst
  作者：Sara S. E. Ghodsinia、Batool Akhlaghinia、Elham Safaei、Hossein Eshghi

  DOI：10.5935/0103-5053.20130115

  日期：——

  N, N',N '', N '''-Tetramethyl tetra-2,3-pyridinoporphyrazinato copper(II) methyl sulfate ([Cu(2,3-tmtppa)](MeSO4)(4)) efficiently catalyzed the direct conversion of nitriles to N-substituted amides. The one pot selective synthesis of the N-substituted amides from nitriles and primary amines was performed in refluxing H2O. The catalyst was recovered and reused at least four times, maintaining its efficiency.