(3-trifluoromethyl-but-3-en-1-ynyl)trimethylsilane | 152327-70-3

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (3-trifluoromethyl-but-3-en-1-ynyl)trimethylsilane
• 英文别名: Trimethyl-[3-(trifluoromethyl)but-3-en-1-ynyl]silane
• CAS: 152327-70-3
• 化学式: C₈H₁₁F₃Si
• 分子量: 192.256
• InChiKey: AHTJKLNMVGLSBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.99
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-氯苯甲醛 、 (3-trifluoromethyl-but-3-en-1-ynyl)trimethylsilane 在 18-冠醚-6 、 cesium fluoride 作用下， 以 四氢呋喃 为溶剂， 以75%的产率得到1-(2-Chloro-phenyl)-4-trifluoromethyl-pent-4-en-2-yn-1-ol
  参考文献：
  名称：

  (3-Trifluoromethyl-but-3-en-1-ynyl)trimethylsilane as a potentially useful CF3-containing building block: preparation and CsF/18-crown-6 ether-catalysed reactions with aldehydes

  摘要：

  A novel CF3-containing building block, (3-trifluoromethyl-but-3-en-1-ynyl)trimethylsilane, has been prepared. It reacted readily with aldehydes in the presence of cesium fluoride and 18-crown-6 ether to afford 2-trifluoromethyl-1-alken-3-ynyl-5-ols.

  DOI：

  10.1016/s0022-1139(00)80390-5
• 作为产物：
  描述：

  2-溴-3,3,3-三氟丙烯 、 三甲基乙炔基硅 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 三正丁胺 作用下， 反应 4.0h， 以95%的产率得到(3-trifluoromethyl-but-3-en-1-ynyl)trimethylsilane
  参考文献：
  名称：

  (3-Trifluoromethyl-but-3-en-1-ynyl)trimethylsilane as a potentially useful CF3-containing building block: preparation and CsF/18-crown-6 ether-catalysed reactions with aldehydes

  摘要：

  A novel CF3-containing building block, (3-trifluoromethyl-but-3-en-1-ynyl)trimethylsilane, has been prepared. It reacted readily with aldehydes in the presence of cesium fluoride and 18-crown-6 ether to afford 2-trifluoromethyl-1-alken-3-ynyl-5-ols.

  DOI：

  10.1016/s0022-1139(00)80390-5

文献信息

• (3-Trifluoromethyl-but-3-en-1-ynyl)trimethylsilane as a potentially useful CF3-containing building block: preparation and CsF/18-crown-6 ether-catalysed reactions with aldehydes
  作者：Chang-ming Hu、Feng Hong、Yuanyao Xu

  DOI：10.1016/s0022-1139(00)80390-5

  日期：1993.7

  A novel CF3-containing building block, (3-trifluoromethyl-but-3-en-1-ynyl)trimethylsilane, has been prepared. It reacted readily with aldehydes in the presence of cesium fluoride and 18-crown-6 ether to afford 2-trifluoromethyl-1-alken-3-ynyl-5-ols.