1-Piperidinyl-(5-thiophen-2-yl-3-isoxazolyl)methanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-Piperidinyl-(5-thiophen-2-yl-3-isoxazolyl)methanone
• 英文别名: piperidin-1-yl-(5-thiophen-2-yl-1,2-oxazol-3-yl)methanone
• 化学式: C₁₃H₁₄N₂O₂S
• mdl: MFCD00110076
• 分子量: 262.33
• InChiKey: LCIGQGPHUWDYGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.384
• 拓扑面积：
  74.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• TREATING CANCER
  申请人：Agency for Science, Technology and Research

  公开号：EP2908843B1

  公开（公告）日：2019-09-04
• EZH2 Cancer Markers
  申请人：Chinnaiyan Arul M.

  公开号：US20090012031A1

  公开（公告）日：2009-01-08

  The present invention relates to therapeutic targets for cancer. In particular, the present invention relates to small molecules and nucleic acids that target EZH2 expression in prostate cancer.
• COMPOUNDS THAT INCREASE TELOMERASE REVERSE TRANSCRIPTASE (TERT) EXPRESSION AND METHODS FOR USING THE SAME
  申请人：Andrews William H.

  公开号：US20090143451A1

  公开（公告）日：2009-06-04

  Compounds, and methods of using the same, are provided which increase the expression of telomerase reverse transcriptase (TERT) in a cell. These compounds and methods find use in a variety of applications in which increased expression of telomerase is desired, including immortalization of cell lines and treating conditions in a subject characterized by cellular senescence.
• COMPOSITIONS AND METHODS FOR INHIBITING EZH2
  申请人：Chinnaiyan Arul M.

  公开号：US20100222420A1

  公开（公告）日：2010-09-02

  The present invention relates to therapeutic targets for cancer. In particular, the present invention relates to small molecules and nucleic acids that target EZH2 expression in prostate cancer.
• METHOD OF TREATING CANCER
  申请人：Agency for Science, Technology and Research

  公开号：US20150258175A1

  公开（公告）日：2015-09-17

  The present invention relates to a pharmaceutical composition comprising a histone-lysine N-methyltransferase EZH2 (enhancer of zeste homolog 2) inhibitor and an enhancer of interferon-gamma receptor activity. The invention also relates to method of treating a patient having cancer, comprising administration of the pharmaceutical composition.