Methyl 3-(benzylamino)thiophene-2-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: Methyl 3-(benzylamino)thiophene-2-carboxylate
• 化学式: C₁₃H₁₃NO₂S
• 分子量: 247.31
• InChiKey: QGKIQYIWOVGRER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  66.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• PROLYL HYDROXYLASE INHIBITORS
  申请人：Fitch Duke M.

  公开号：US20090176825A1

  公开（公告）日：2009-07-09

  The invention described herein relates to certain bicyclic heteroaromatic N-substituted glycine derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.

  本发明涉及公式(I)的某些双环杂环N-取代甘氨酸衍生物，它们是HIF脯氨酸羟化酶的拮抗剂，适用于治疗受益于抑制该酶的疾病，例如贫血。
• Heterocyclic amides
  申请人：BEECHAM GROUP PLC

  公开号：EP0227431A1

  公开（公告）日：1987-07-01

  A compound of formula (I): or a salt, ester, amide or solvate thereof, in which, R. represents hydrogen, substituted or unsubstituted alkyl or an acyl group; Rb and Rc are independently hydrogen or a substituted or unsubstituted aryl group or a group -ORa; or Rb and Rc together with the carbon atoms to which they are attached form a substituted or unsubstituted carbocyclic group; Rd and Re are independently hydrogen, substituted or unsubstituted aryl or a group -ORa; or Rd and Re together with the carbon atoms to which they are attached form a substituted or unsubstituted carbocyclic group; A' represents an alkylene or an alkenylene group; A2 represents hydrogen, substituted or unsubstituted alkyl or an aralkyl group substituted or unsubstituted in the aryl moiety; and Het represents a substituted or unsubstituted heterocyclic group; a process for preparing such a compound, a pharmaceutical composition containing such a compound and the use of such compounds and compositions in medicine.

  式(I)化合物： 或其盐、酯、酰胺或溶液，其中 R. 代表氢、取代或未取代的烷基或酰基； Rb 和 Rc 独立地是氢、取代或未取代的芳基或基团 -ORa；或 Rb 和 Rc 与它们所连接的碳原子一起形成取代或未取代的碳环基团； Rd和Re独立地为氢、取代或未取代的芳基或基团-ORa；或Rd和Re与其所连接的碳原子一起形成取代或未取代的碳环基团； A' 代表亚烷基或烯基； A2 代表氢、取代或未取代的烷基或芳基中取代或未取代的芳烷基； Het 代表取代或未取代的杂环基团；制备这种化合物的工艺、含有这种化合物的药物组合物以及这种化合物和组合物在医药中的用途。
• [EN] PROLYL HYDROXYLASE INHIBITORS<br/>[FR] INHIBITEURS DE PROLYL HYDROXYLASE
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2007136990A2

  公开（公告）日：2007-11-29

  [EN] The invention described herein relates to certain bicyclic heteroaromatic N-substituted glycine derivatives of formula (I ) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
  [FR] L'invention décrite ici concerne certains dérivés de glycine N-substitués hétéro-aromatiques bicycliques de formule (I) qui sont des antagonistes de HIF prolyl hydroxylases et sont utiles pour traiter les maladies bénéficiant de l'inhibition de cet enzyme, l'anémie en étant un exemple.