(2'S)-2-<(2'-hydroxy-3'-trityloxypropyl)amino>propane-1,3-diol | 164212-17-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: (2'S)-2-<(2'-hydroxy-3'-trityloxypropyl)amino>propane-1,3-diol
• 英文别名: 2-[[(2S)-2-hydroxy-3-trityloxypropyl]amino]propane-1,3-diol
• CAS: 164212-17-3
• 化学式: C₂₅H₂₉NO₄
• 分子量: 407.51
• InChiKey: OHJUCMUMHZPTDN-DEOSSOPVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  30
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  82
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (2'S)-2-<(2'-hydroxy-3'-trityloxypropyl)amino>propane-1,3-diol 在 乙酰氯 作用下， 以 甲醇 为溶剂， 反应 168.0h， 以93%的产率得到(2'S)-2-<(2',3'-dihydroxypropyl)amino>propane-1,3-diol hydrochloride
  参考文献：
  名称：

  Synthesis and biological activity of acyclic anlogues of nojirimycin

  摘要：

  A series of acyclic compounds has been prepared which comprises compounds that mimic key structural elements of nojirimycin 1 and 1-deoxynojirimycin 2, both of which are highly effective glucosidase inhibitors, in order to ascertain if similar biological activity can be obtained with simpler structures. All of the compounds are competitive inhibitors of yeast alpha-glucosidase. with varying degrees of effectiveness, but none of them, in contrast to 1-deoxynojirimycin 2, show significant anti-HIV activity.

  DOI：

  10.1039/p19940002229
• 作为产物：
  描述：

  丝氨醇 、 三苯甲基-(S)-缩水甘油醚 以 甲醇 为溶剂， 反应 144.0h， 以46%的产率得到(2'S)-2-<(2'-hydroxy-3'-trityloxypropyl)amino>propane-1,3-diol
  参考文献：
  名称：

  Synthesis and biological activity of acyclic anlogues of nojirimycin

  摘要：

  A series of acyclic compounds has been prepared which comprises compounds that mimic key structural elements of nojirimycin 1 and 1-deoxynojirimycin 2, both of which are highly effective glucosidase inhibitors, in order to ascertain if similar biological activity can be obtained with simpler structures. All of the compounds are competitive inhibitors of yeast alpha-glucosidase. with varying degrees of effectiveness, but none of them, in contrast to 1-deoxynojirimycin 2, show significant anti-HIV activity.

  DOI：

  10.1039/p19940002229

文献信息

• Synthesis and biological activity of acyclic anlogues of nojirimycin
  作者：Paul A. Fowler、Alan H. Haines、Richard J. K. Taylor、Ewan J. T. Chrystal、Michael B. Gravestock

  DOI：10.1039/p19940002229

  日期：——

  A series of acyclic compounds has been prepared which comprises compounds that mimic key structural elements of nojirimycin 1 and 1-deoxynojirimycin 2, both of which are highly effective glucosidase inhibitors, in order to ascertain if similar biological activity can be obtained with simpler structures. All of the compounds are competitive inhibitors of yeast alpha-glucosidase. with varying degrees of effectiveness, but none of them, in contrast to 1-deoxynojirimycin 2, show significant anti-HIV activity.