5-(1-methyl-5-trifluoromethyl-1H-pyrazol-3-yl)-thiophene-2-sulfonic acid amide | 799774-65-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 5-(1-methyl-5-trifluoromethyl-1H-pyrazol-3-yl)-thiophene-2-sulfonic acid amide
• 英文别名: 5-[1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]thiophene-2-sulfonamide；5-[1-methyl-5-(trifluoromethyl)pyrazol-3-yl]thiophene-2-sulfonamide
• CAS: 799774-65-5
• 化学式: C₉H₈F₃N₃O₂S₂
• 分子量: 311.309
• InChiKey: DOSZVTCIVRRSHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  115
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  2-(2,2-Dimethyl-5-oxo-[1,3]dioxolan-4-ylidene)-N-(4-fluoro-benzyl)-N-methoxy-acetamide 、 5-(1-methyl-5-trifluoromethyl-1H-pyrazol-3-yl)-thiophene-2-sulfonic acid amide 、 生成 3-Hydroxy-4-[5-(1-methyl-5-trifluoromethyl-1H-pyrazol-3-yl)-thiophene-2-sulfonylamino]-4-oxo-but-2-enoic acid (4-fluoro-benzyl)-methoxy-amide
  参考文献：
  名称：

  Acyl sulfonamides as inhibitors of HIV integrase

  摘要：

  本发明涉及一系列公式I中的化合物，其中R1、R2、R3和B如规范中所定义。该化合物可用于抑制HIV整合酶并通过给予该公式的化合物治疗艾滋病或ARC。

  公开号：

  US20050004232A1

文献信息

• Therapeutic Compounds
  申请人：Zhou Xianbo

  公开号：US20070203154A1

  公开（公告）日：2007-08-30

  The invention provides a compound of formula I: wherein R 1 -R 6 , X, Y, and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of MAO-B enzyme function and are useful for improving cognitive function and for treating psychiatric disorders in animals.

  这项发明提供了一个式I的化合物： 其中R1-R6，X，Y和B具有本文所述的任何值，以及这些化合物的盐、包含这些化合物的组合物，以及包括给予这些化合物的治疗方法。这些化合物是MAO-B酶功能的抑制剂，对于改善认知功能和治疗动物的精神障碍是有用的。
• Novel Pyridine Compounds
  申请人：Bach Peter

  公开号：US20090227555A2

  公开（公告）日：2009-09-10

  The present invention relates to certain novel pyridin compounds of Formula (I) to processes for preparing such compounds, to their utility as P2Y12 inhibitors and as anti-thrombotic agents etc, and processes for their preparation, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.

  本发明涉及某些新型的Formula (I)吡啶化合物，以及制备这些化合物的方法，它们作为P2Y12抑制剂和抗血栓剂等的用途，以及它们的制备过程，它们在心血管疾病中作为药物的用途，以及包含它们的制药组合物。
• Preparation of stabilized manganese(II) ethylene-bis(dithiocarbamate) and fungicidal compositions containing it
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0008533A1

  公开（公告）日：1980-03-05

  Manganese (II) ethylenebis(dithiocarbamate) of low ethylenethiourea content can be prepared by mixing disodium ethylenebis(dithiocarbamate) with formaldehyde in aqueous medium then mixing a water-soluble manganese (II) salt to precipitate the maneb. The product can be further formulated with a metal salt and also with paraformaldehyde. Fungicidal compositions may be prepared by formulating with conventional carriers or adjuvants.

  低乙硫脲含量的乙撑双二硫代氨基甲酸锰（II）可通过在水介质中将乙撑双二硫代氨基甲酸二钠与甲醛混合，然后混合水溶性锰（II）盐以沉淀芒硝来制备。 该产品可进一步与金属盐和多聚甲醛配制。 可通过与常规载体或佐剂配制来制备杀菌组合物。
• Synergistic fungicidal composition
  申请人：UNIROYAL LIMITED

  公开号：EP0209234A2

  公开（公告）日：1987-01-21

  Compositions comprised of (A) certain substituted carboxamidothiazoles and (B) one or more compounds selected from the group consisting of imidazoles, triazoles, guanadines, halonitrobenzenes, manganese and zinc salts of ethylene-bis-(dithiocarbamate), pyrimidines, dicarboxamides, pyrrolidines and thiurams exhibit synergistic fungicidal activity. Also, a method for protecting plants from fungal disease comprising treating such plants with a fungicidally effective amount of said composition is disclosed.

  由(A)某些取代的羧酰胺基噻唑和(B)一种或多种选自咪唑类、三唑类、胍类、卤代硝基苯类、乙烯双二硫代氨基甲酸酯的锰盐和锌盐、嘧啶类、二羧酰胺类、吡咯烷类和秋兰姆类的化合物组成的组合物显示出协同杀真菌活性。此外，还公开了一种保护植物免受真菌疾病侵害的方法，该方法包括用杀真菌有效量的上述组合物处理这些植物。
• Biocide activator
  申请人：KAO CORPORATION

  公开号：EP0509346A1

  公开（公告）日：1992-10-21

  A biocide composition comprising (A) 1 to 50% by weight of a biocide, and (B) 0.005-60% by weight of a biocide activator having the specific formula is provided. The biocide effect of a biocide can be enhanced with the use of an effective amount of a biocide activator.

  一种杀菌剂组合物，包括 (A) 1 至 50%（按重量计）的杀菌剂，和 (B) 0.005-60%（按重量计）具有特定配方的杀菌剂活化剂。使用有效量的杀菌剂活化剂可增强杀菌剂的杀菌效果。