N-[2,2,2-trichloro-1-(cyclohexylamino)ethyl]thiophene-2-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: N-[2,2,2-trichloro-1-(cyclohexylamino)ethyl]thiophene-2-carboxamide
• 化学式: C₁₃H₁₇Cl₃N₂OS
• 分子量: 355.7
• InChiKey: CLMJESKGHLCROD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  69.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] SMALL MOLECULES TO BLOCK SIGNALING PATHWAY<br/>[FR] PETITES MOLÉCULES POUR BLOQUER LA VOIE DE SIGNALISATION
  申请人：UNIV CALIFORNIA

  公开号：WO2014120790A1

  公开（公告）日：2014-08-07

  Methods and compositions of this invention relate to suppressing Ca2+-Release-Activated- Ca2+ (CRAC) channel activity using novel compounds of Formula (I): Compounds of formula (I) have been shown to modulate calcium transport through the CRAC channel. The function of the CRAC channel is important for the immune response and is largely limited to cells of the immune system. Accordingly, in one aspect, there is provided a method for suppressing immunity in a mammal in need thereof comprising administering a compound of Formula (I) in an amount sufficient to inhibit CRAC channel activity. Also provided are pharmaceutical compositions and kits comprising compounds of formula (I).