4-ethyl-2-methyl-piperidine | 93029-89-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-ethyl-2-methyl-piperidine
• 英文别名: 4-Aethyl-2-methyl-piperidin；4-Ethyl-2-methylpiperidine
• CAS: 93029-89-1
• 化学式: C₈H₁₇N
• 分子量: 127.23
• InChiKey: OGQRYSIZUFPQLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-乙基-2-甲基吡啶 在 乙醇 、 sodium 作用下， 生成 4-ethyl-2-methyl-piperidine
  参考文献：
  名称：

  Ladenburg; Schultz, Justus Liebigs Annalen der Chemie, 1888, vol. 247, p. 96

  摘要：

  DOI：

文献信息

• NOVEL LUPANE DERIVATIVES
  申请人：Moinet Christophe

  公开号：US20110077227A1

  公开（公告）日：2011-03-31

  The invention relates to 21-keto triterpene compounds of formula (I): wherein R 1 , X, and Y are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit significant anti-HIV activity. Thus, the invention also relates to methods for prevention or treatment of HIV infections by administering therapeutically effective amounts of a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof to a subject in need of such treatment.

  该发明涉及式(I)的21-酮三萜化合物：其中R1、X和Y如本文所定义，并且其药学上可接受的盐和溶剂化合物。这些化合物表现出显著的抗HIV活性。因此，该发明还涉及通过向需要此类治疗的受试者施用式(I)的化合物、或其药学上可接受的盐或溶剂化合合物的治疗有效量来预防或治疗HIV感染的方法。
• NOVEL C-21-KETO LUPANE DERIVATIVES PREPARATION AND USE THEREOF
  申请人：Moinet Christophe

  公开号：US20110077228A1

  公开（公告）日：2011-03-31

  The invention relates to 21-keto triterpene compounds of formula (I): wherein R 1 , X and Y are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit significant anti-HIV activity. Thus, the invention also relates to methods for prevention or treatment of HIV infections by administering therapeutically effective amounts of a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof to a subject in need of such treatment.

  该发明涉及式(I)的21-酮三萜化合物：其中R1、X和Y如本文所定义，并且其药用可接受的盐和溶剂化合物。这些化合物表现出显著的抗HIV活性。因此，该发明还涉及通过向需要此类治疗的受试者施用式(I)的化合物或其药用可接受的盐或溶剂，来预防或治疗HIV感染的方法。
• [EN] HETEROCYCLIC COMPOUNDS AS KINASE INHIBITOR AND USES THEREOF<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES UTILISÉS EN TANT QU'INHIBITEURS DE KINASE ET LEURS UTILISATIONS
  申请人：INTEGRAL BIOSCIENCES PVT LTD

  公开号：WO2021019514A1

  公开（公告）日：2021-02-04

  The present disclosure relates generally to compounds useful in treatment of conditions associated with Checkpoint kinase (CHK), particularly CHK-1 enzymes. Specifically, the present invention discloses compound of formula (IA), which exhibits inhibitory activity against CHK-1 enzymes. Methods of treating conditions associated with excessive activity of CHK-1 enzymes with such compounds is disclosed. Uses thereof, pharmaceutical compositions, kits and method of synthesis also disclosed.

  本公开涉及一般用于治疗与检查点激酶（CHK）相关疾病的化合物，特别是CHK-1酶。具体地，本发明揭示了式（IA）的化合物，该化合物对CHK-1酶具有抑制活性。公开了使用这些化合物治疗与CHK-1酶过度活性相关的疾病的方法。还公开了这些化合物的用途、制药组合物、试剂盒和合成方法。
• BENZIMIDAZOLE ANALOGUES FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS
  申请人：Henderson James A.

  公开号：US20110172238A1

  公开（公告）日：2011-07-14

  Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein A, B, B′, X, Y, R 1 , R 1 ′, R 2 , R 2 ′, R 3 , R 3 ′, R 5 , R 5 ′, R 6 , m, n, or p are as defined herein, are useful for treating flaviviridae viral infections.

  公式I所代表的化合物，或其药学上可接受的盐和溶剂化物，其中A、B、B'、X、Y、R1、R1'、R2、R2'、R3、R3'、R5、R5'、R6、m、n或p的定义如本文所述，可用于治疗黄病毒科病毒感染。
• INDAZOLE- AND PYRROLOPYRIDINE-DERIVATIVE AND PHARMACEUTICAL USE THEREOF
  申请人：Mizuno Kazuhiro

  公开号：US20140057895A1

  公开（公告）日：2014-02-27

  The present invention relates to a novel indazole- or pyrrolopyridine-derivative comprising a 5 membered heterocyclic substituent at 1 position thereof which has an agonistic action or a partial agonistic action against serotonin-4 receptor, and a pharmaceutical composition comprising the same.

  本发明涉及一种新型吲唑或吡咯吡啶衍生物，其在1位具有一个5成员杂环取代基，具有对5-羟色胺-4受体的激动作用或部分激动作用，以及包含该衍生物的药物组合物。