3-(4-pyridyl)-3H-1,2,3-triazolo[4,5-b]pyridine | 62052-28-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三唑并吡啶类
• 英文名称: 3-(4-pyridyl)-3H-1,2,3-triazolo[4,5-b]pyridine
• 英文别名: 3-(4-Pyridyl)-3H-1,2,3-triazolo(4,5-b)pyridin；3-pyridin-4-yl-3H-[1,2,3]triazolo[4,5-b]pyridine；3-(Pyridin-4-yl)-3H-[1,2,3]triazolo[4,5-b]pyridine；3-pyridin-4-yltriazolo[4,5-b]pyridine
• CAS: 62052-28-2
• 化学式: C₁₀H₇N₅
• 分子量: 197.199
• InChiKey: UXWUORNSCMGUKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  56.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-Nitro-2-(4-pyridylamino)-pyridin 在 盐酸 、 sodium dithionite 、 sodium nitrite 作用下， 以 乙醇 、 水 为溶剂， 反应 4.0h， 生成 3-(4-pyridyl)-3H-1,2,3-triazolo[4,5-b]pyridine
  参考文献：
  名称：

  Use of the Graebe-Ullmann reaction in the synthesis of 8-methyl-γ-carboline and isomeric aromatic aza-γ-carbolines

  摘要：

  Two variants of the Graebe-Ullmann reaction were used to obtain 8-methyl-5H-pyrido[4,3-b]indole (8-methyl-gamma-carboline) and the conditions for this reaction were optimized. The feasibility of using this method was studied for the synthesis of a series of isomeric aromatic aza-gamma-carbolines from the corresponding 1-(pyridyl)-1H-1,2,3-triazolo[4,5-c]pyridines under thermal and microwave irradiation conditions.

  DOI：

  10.1007/s10593-012-1127-7

文献信息

• 3-Phenyl,3H 1,2,3 triazolo[4,5-b]pyridines
  申请人：Merck & Co., Inc.

  公开号：US04000286A1

  公开（公告）日：1976-12-28

  3H-1,2,3-Triazolo[4,5-b]pyridines substituted in the 3-position have utility as analgesic, anti-inflammatory and anti-pyretic agents. They are prepared by diazotization of a 3-amino-2-(substitute) aminopyridine.

  在3位取代的3H-1,2,3-三氮唑[4,5-b]吡啶中，具有镇痛、抗炎和退热作用。它们是通过对3-氨基-2-(取代)氨基吡啶进行重氮化制备的。
• J. MED. CHEM., 1978, 21, NO 9, 965-978
  作者：

  DOI：——

  日期：——
• US4000286A
  申请人：——

  公开号：US4000286A

  公开（公告）日：1976-12-28
• Use of the Graebe-Ullmann reaction in the synthesis of 8-methyl-γ-carboline and isomeric aromatic aza-γ-carbolines
  作者：R. S. Alekseev、A. V. Kurkin、M. A. Yurovskaya

  DOI：10.1007/s10593-012-1127-7

  日期：2012.11

  Two variants of the Graebe-Ullmann reaction were used to obtain 8-methyl-5H-pyrido[4,3-b]indole (8-methyl-gamma-carboline) and the conditions for this reaction were optimized. The feasibility of using this method was studied for the synthesis of a series of isomeric aromatic aza-gamma-carbolines from the corresponding 1-(pyridyl)-1H-1,2,3-triazolo[4,5-c]pyridines under thermal and microwave irradiation conditions.