(N-Benzoylamino)-4-benzyl-1-isonipecotinsaeure-ethylester | 57611-87-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (N-Benzoylamino)-4-benzyl-1-isonipecotinsaeure-ethylester
• 英文别名: 4-benzoylamino-1-benzyl-piperidine-4-carboxylic acid ethyl ester；4-Piperidinecarboxylic acid, 4-(benzoylamino)-1-(phenylmethyl)-, ethyl ester；ethyl 4-benzamido-1-benzylpiperidine-4-carboxylate
• CAS: 57611-87-7
• 化学式: C₂₂H₂₆N₂O₃
• 分子量: 366.46
• InChiKey: OFAPPWLBKLIMDL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• 8-METHOXYQUINOLONECARBOXYLIC ACID DERIVATIVE
  申请人：YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD.

  公开号：EP0677522A1

  公开（公告）日：1995-10-18

  An 8-methoxyquinolonecarboxylic acid derivative represented by general formula (I), and optical isomers, pharmaceutically acceptable salts and hydrates thereof, wherein R₁ represents hydrogen, lower alkyl, phenylalkyl or an in vivo hydrolyzable ester residue; R₂ represents hydrogen or methyl; and n represents an integer of 0 or 1. This derivative has a wide antimicrobial spectrum based on the activity potentiated in vitro and in vivo against gram-positive bacteria while retaining the potent antibacterial activity of the conventional quinolonecarboxylate bactericides against gram-negative bacteria. Since it scarcely has problematic side effects and is reduced in toxicity, it is promising as a bactericide having more excellent clinical effects.

  通式(I)代表的 8-甲氧基喹啉羧酸衍生物及其光学异构体、药学上可接受的盐和水合物，其中 R₁ 代表氢、低级烷基、苯基烷基或体内可水解的酯残基；R₂ 代表氢或甲基；n 代表 0 或 1 的整数。根据体外和体内对革兰氏阳性菌的增效活性，这种衍生物具有广泛的抗菌谱，同时保留了传统喹啉羧酸盐杀菌剂对革兰氏阴性菌的强效抗菌活性。由于它几乎没有副作用，毒性也较低，因此有望成为一种临床效果更佳的杀菌剂。