1-ethenyl-3-methyl-2H-imidazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: 1-ethenyl-3-methyl-2H-imidazole
• 化学式: C₆H₁₀N₂
• 分子量: 110.16
• InChiKey: WLWHLUQQCLCFNE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• CONJUGATE-BASED ANTIFUNGAL AND ANTIBACTERIAL PRODRUGS
  申请人：Bapat Abhijit S.

  公开号：US20140364595A1

  公开（公告）日：2014-12-11

  The invention provides conjugate-based antifungal or antibacterial prodrugs formed by coupling at least one anti-fungal agent or antibacterial agent with at least one linker and/or carrier. The prodrugs are of formula: (i) (AFA) m -X-(L) n ; (ii) [(AFA) m′ -X] p -L; (iii) AFA-[X-(L) n′ ] q ; or (iv) (AFA) m″ -X, wherein: AFA is an antifungal agent or an antibacterial agent; L is a carrier; X is a linker; m ranges from 1 to 10; n ranges from 2 to 10; m′ is 1 to 10; p is 1 to 10; n′ is 1 to 10; and q is 1 to 10, provided that q′ and n are not both 1; and m″ is 1 to 10. The invention also provides nanoparticles comprising the conjugate-based prodrugs. Additionally, the invention also provides non-conjugated antifungal and antibacterial agents in the form of nanoparticles.

  该发明提供了由至少一种抗真菌剂或抗菌剂与至少一种连接剂和/或载体偶联形成的基于共轭的抗真菌或抗菌前药。这些前药的公式为：(i) (AFA) m -X-(L) n ; (ii) [(AFA) m′ -X] p -L; (iii) AFA-[X-(L) n′ ] q ; 或 (iv) (AFA) m″ -X，其中：AFA是抗真菌剂或抗菌剂；L是载体；X是连接剂；m范围从1到10；n范围从2到10；m′为1到10；p为1到10；n′为1到10；q为1到10，前提是q'和n不同时为1；m″为1到10。该发明还提供了包含基于共轭的前药的纳米粒子。此外，该发明还提供了以纳米粒子形式的非共轭抗真菌和抗菌剂。
• Organic Colorant Complexes from Reactive Dyes and Articles Containing the Same
  申请人：Milliken & Company

  公开号：US20150299468A1

  公开（公告）日：2015-10-22

  An organic colorant complex with the following general structure: AB n (DE) m T x Q y wherein A is an organic chromophore; B is an electrophilic reactive group covalently bonded to A directly or through a linking group; D is a nucleophilic linking group covalently bonding B and E, selected from the group consisting of NR, O, S, and 4-oxyanilino (—HN-Ph-O—); wherein R is selected from the group consisting of H, alkyl, aryl, and E; E is an organic alkyl and aryl group or an end group; T is an ionic group covalently linked to A; O is an organic cation, bonded to the organic chromophore A through ionic interaction with T; n, m, x, and y are independent integers from 1 to 10.

  具有以下一般结构的有机着色剂复合物：ABn(DE)mTxQy其中A是有机色团；B是与A直接或通过连接基团共价键合的亲电性反应基团；D是共价键合B和E的亲核连接基团，选自NR、O、S和4-氧基苯胺基（—HN-Ph-O—）组成的群；其中R选自H、烷基、芳基和E组成的群；E是有机烷基和芳基或末端基团；T是与A共价连接的离子基团；O是有机阳离子，通过与T的离子相互作用与有机色团A结合；n、m、x和y是独立的1至10之间的整数。
• Branched Polymeric Emulsifiers
  申请人：Lubrizol Advanced Materials, Inc.

  公开号：US20150218312A1

  公开（公告）日：2015-08-06

  The present invention relates to esterified glycerylated alkyl glycoside and to a process for making same. The esterified glycerylated alkyl glycoside have one or more polyglyceryl moieties and one or more acyl moieties, wherein all of the one or more acyl moieties are situated on the one or more polyglyceryl moieties via an ester linkage. These compounds have been found to be useful as emulsifiers and coemulsifiers in the formulation of a phase stable emulsions suitable for use in personal care, home care, industrial and institutional, and health care applications.

  本发明涉及酯化的甘油化烷基葡糖苷以及制备该化合物的方法。所述的酯化的甘油化烷基葡糖苷具有一个或多个聚甘油基团和一个或多个酰基团，其中所有的一个或多个酰基团通过酯键位于一个或多个聚甘油基团上。已发现这些化合物在制备适用于个人护理、家庭护理、工业和机构、以及医疗保健应用的相稳定乳化剂和共乳化剂方面具有实用性。
• AQUEOUS HAIR CLEANSING AGENT
  申请人：KAO CORPORATION

  公开号：US20140079658A1

  公开（公告）日：2014-03-20

  The invention relates to an aqueous hair cleansing agent comprising the following components (A), (B), (C), and water and having a pH of 2 to 5 at 25° C. when diluted 20-fold by mass with water: (A) an internal olefin sulfonate, (B) an organic solvent selected from the group consisting of the following (B1) to (B5): (B1) an aromatic alcohol, (B2) a polypropylene glycol, (B3) a N-alkyl pyrrolidone, (B4) an alkylene carbonate, (B5) a lactone or a cyclic ketone, and (C) an organic carboxylic acid selected from the group consisting of a hydroxymonocarboxylic acid and dicarboxylic acid.

  该发明涉及一种含有以下组分（A）、（B）、（C）和水的水性头发清洁剂，当与水按质量稀释20倍时，在25°C时的pH值为2至5：（A）内部烯烃磺酸盐，（B）从以下组（B1）到（B5）中选择的有机溶剂：（B1）芳香醇，（B2）聚丙烯醚，（B3）N-烷基吡咯烷酮，（B4）烷基碳酸酯，（B5）内酯或环酮，以及（C）从羟基单羧酸和二羧酸组成的羧酸中选择的有机羧酸。
• Antimicrobial compositions and methods
  申请人：Scholz T. Matthew

  公开号：US20050058673A1

  公开（公告）日：2005-03-17

  Antimicrobial compositions, especially those useful when applied topically, particularly to mucosal tissues (i.e., mucous membranes), including a fatty acid ester, fatty ether, or alkoxide derivative thereof. The compositions can also include an enhancer component, a surfactant, a hydrophobic component, and/or a hydrophilic component. Such compositions provide effective topical antimicrobial activity and are accordingly useful in the treatment and/or prevention of conditions that are caused, or aggravated by, microorganisms (including viruses).

  抗微生物组合物，特别是在局部应用时有用的组合物，特别是应用于黏膜组织（即粘膜）的组合物，包括脂肪酸酯，脂肪醚或其烷氧基衍生物。这些组合物还可以包括增效剂成分，表面活性剂，疏水性成分和/或亲水性成分。这些组合物提供有效的局部抗微生物活性，因此在治疗和/或预防由微生物（包括病毒）引起或加重的疾病方面具有用处。