2-(3-ethyl-4-methyl-2H-1,3-thiazol-5-yl)ethanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: 2-(3-ethyl-4-methyl-2H-1,3-thiazol-5-yl)ethanol
• 化学式: C₈H₁₅NOS
• 分子量: 173.28
• InChiKey: DYHLCRZZXWSFHY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  48.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• GAMMA-DIKETONES AS WNT/BETA -CATENIN SIGNALING PATHWAY ACTIVATORS
  申请人：Samumed, LLC

  公开号：US20140243349A1

  公开（公告）日：2014-08-28

  The present disclosure provides γ-diketones or analogs thereof, that activate Wnt/β-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries or spine injuries, brain atrophy/neurological disorders related to the differentiation and development of the central nervous system, including Parkinson's disease, strokes, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; otic disorders like cochlear hair cell loss; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, such as hair loss, hematopoiesis related diseases and tissue regeneration related diseases.

  本公开提供了激活Wnt/β-连环蛋白信号通路并因此治疗或预防与信号转导相关的疾病的γ-二酮或其类似物；这些疾病包括骨质疏松症和骨关节病；骨发育不全、骨缺陷、骨折、牙周病、耳硬化症、伤口愈合、颅颌面缺陷、溶骨性骨病、创伤性脑损伤或脊柱损伤、与中枢神经系统分化和发育相关的脑萎缩/神经系统疾病，包括帕金森病、中风、缺血性脑疾病、癫痫、阿尔茨海默病、抑郁症、躁郁症、精神分裂症；耳部疾病如耳蜗毛细胞丧失；眼部疾病如老年性黄斑变性、糖尿病性黄斑水肿或视网膜色素变性以及与干细胞分化和生长相关的疾病，如脱发、造血相关疾病和组织再生相关疾病。
• Process for preparing C7 intermediates and their use in the preparation on N-substituted pyrrole derivatives
  申请人：Ratiopharm GmbH

  公开号：EP1834944A1

  公开（公告）日：2007-09-19

  The present invention relates to a process for preparing C7 intermediates and their use in the preparation of pyrrole derivatives of a class that is effective at inhibiting the biosynthesis of cholesterol in humans, and more particularly to improved synthetic methods for preparing 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids. The invention further relates to intermediates in this process.

  本发明涉及一种制备C7中间体并在制备对人体胆固醇生物合成具有效抑制作用的吡咯类衍生物中的应用的方法，更具体地涉及用于制备3,5-二羟基-7-吡咯-1-基庚酸的改进合成方法。该发明还涉及该过程中的中间体。
• Verfahren zur Herstellung von 2,3-Epoxyamiden
  申请人：BAYER AG

  公开号：EP0244717A2

  公开（公告）日：1987-11-11

  Die Erfindung betrifft ein Verfahren zur Herstellung von 2,3-Epoxyamiden der allgemeinen Formel (I) in welcher R1, R2, und R3 die in der Beschreibung angegebene Bedeutung besitzen und die wichtige Zwischenprodukte zur Synthese von Carbapenemantibiotika sind.

  本发明涉及一种通式（I）的 2,3-环氧酰胺的制备工艺，其中 R1、R2 和 R3 的含义如描述中所述，它们是合成碳青霉烯类抗生素的重要中间体。
• DYE-SENSITIZED SOLAR CELL AND METHOD OF MANUFACTURING SAME
  申请人：ADEKA CORPORATION

  公开号：EP2833471A1

  公开（公告）日：2015-02-04

  The object of the invention is to provide a dye-sensitized solar cell and a method for making the same that allow for greatly broadening the light absorption wavelength range without using a metal complex dye, thereby achieving excellent photovoltaic characteristics. The dye-sensitized solar cell of the invention includes a photoelectrode having a substrate, a transparent conductive layer on the substrate, and a metal oxide porous layer containing metal oxide particles on the transparent conductive layer. The metal oxide porous layer has sensitizing dyes adsorbed thereon. The sensitizing dyes includes an organic cyanine dye and an indoline dye having an indoline structure. The organic cyanine dye and the indoline dye are supported by the metal oxide porous layer in a plurality of levels such that the organic cyanine dye is present in a higher concentration than the indoline dye on the surface of the metal oxide particles.

  本发明的目的是提供一种染料敏化太阳能电池及其制造方法，这种电池可以在不使用金属络合染料的情况下大大拓宽光吸收波长范围，从而获得优异的光电特性。本发明的染料敏化太阳能电池包括一个光电极，该光电极具有一个基板，基板上有一个透明导电层，透明导电层上有一个含有金属氧化物颗粒的金属氧化物多孔层。金属氧化物多孔层上吸附有敏化染料。敏化染料包括有机氰染料和具有吲哚啉结构的吲哚啉染料。有机氰染料和吲哚啉染料以多个层次被金属氧化物多孔层吸附，在金属氧化物颗粒表面，有机氰染料的浓度高于吲哚啉染料。
• GAMMA-DIKETONES AS WNT/BETA-CATENIN SIGNALLING PATHWAY ACTIVATORS
  申请人：Samumed, LLC

  公开号：EP3456325A2

  公开（公告）日：2019-03-20

  The present disclosure provides γ-diketones or analogs thereof, that activate Wnt/β-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries or spine injuries, brain atrophy/neurological disorders related to the differentiation and development of the central nervous system, including Parkinson's disease, strokes, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; otic disorders like cochlear hair cell loss; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, such as hair loss, hematopoiesis related diseases and tissue regeneration related diseases.

  本公开提供了γ-二酮或其类似物，它们能激活Wnt/β-catenin信号转导，从而治疗或预防与信号转导有关的疾病，如骨质疏松症和骨关节病；成骨不全症、骨缺损、骨折、牙周病、耳硬化症、伤口愈合、颅面缺损、溶瘤性骨病、脑外伤或脊柱损伤、脑萎缩/与中枢神经系统分化和发育有关的神经系统疾病，包括帕金森病、中风、缺血性脑病、癫痫、阿尔茨海默病、抑郁症、躁狂症、精神分裂症；耳部疾病，如耳蜗毛细胞缺失；眼部疾病，如老年性黄斑变性、糖尿病性黄斑水肿或视网膜色素变性；以及与干细胞分化和生长有关的疾病，如脱发、造血相关疾病和组织再生相关疾病。