hydron;N-[[2-methoxy-5-[5-(trifluoromethyl)tetrazol-1-yl]phenyl]methyl]-2-phenylpiperidin-3-amine;dichloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: hydron;N-[[2-methoxy-5-[5-(trifluoromethyl)tetrazol-1-yl]phenyl]methyl]-2-phenylpiperidin-3-amine;dichloride
• 化学式: C21H25Cl2F3N6O
• 分子量: 505.4
• InChiKey: YVNRXILPJNISEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.12
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  76.9
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• 2-METHOXY-5-(5-TRIFLUOROMETHYL-TETRAZOL-1-YL-BENZYL)-2S-PHENYL-PIPERIDIN-3S-YL)-AMINE FOR THE TREATMENT OF SOCIAL PHOBIA
  申请人：GLAXO GROUP LIMITED

  公开号：EP1713482A1

  公开（公告）日：2006-10-25
• MEDICAMENT
  申请人：GLAXO GROUP LIMITED

  公开号：EP1737456A1

  公开（公告）日：2007-01-03
• 2-Methoxy-5(5-trifluoromethyl-tetrazol-1-yl-benzyl)-2s-phenyl-piperdin-3s-yl)-amine for the treatment of social phobia
  申请人：Bani Massimo

  公开号：US20070060617A1

  公开（公告）日：2007-03-15

  The present invention provides the a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof or pharmaceutical compositions containing the same for the treatment of social phobia (otherwise known as Social Anxiety Disorder).
• Medicament
  申请人：Ratti Emiliangelo

  公开号：US20070219247A1

  公开（公告）日：2007-09-20

  This invention provides the use of the compound [2-methoxy-5-(5-trifluoromethyl-tetrazol-1-yl-benzyl)]-([2S,3S]-2-phenyl-piperidin-3-yl)-amine, pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing them for the manufacture of a medicament for the treatment or prevention of Posttraumatic Stress Disorder (PTSD).
• [EN] 2-METHOXY-5-(5-TRIFLUOROMETHYL-TETRAZOL-1-YL-BENZYL)-2S-PHENYL-PIPERIDIN-3S-YL)-AMINE FOR THE TREATMENT OF SOCIAL PHOBIA<br/>[FR] 2-METHOXY-5-(5-TRIFLUOROMETHYL-TETRAZOL-1-YL-BENZYL)-2S-PHENYL-PIPERIDIN-3S-YL)-AMINE POUR LE TRAITEMENT DE PHOBIE SOCIALE
  申请人：GLAXO GROUP LTD

  公开号：WO2005077367A1

  公开（公告）日：2005-08-25

  The present invention provides the use of a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof or pharmaceutical compositions containing them, for the manufacture of a medicament for the treatment of social phobia (otherwise known as Social Anxiety Disorder).