1,3-Diethyl-6-methyl-piperidin | 94599-69-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1,3-Diethyl-6-methyl-piperidin
• 英文别名: 1,5-Diethyl-2-methylpiperidin；N-Ethyl-3-ethyl-6-methylpiperidin；3-Aethyl-6-methyl-1-aethyl-piperidin；N-Aethyl-3-aethyl-6-methyl-piperidin；1,5-diethyl-2-methyl-piperidine；1,5-Diethyl-2-methylpiperidine
• CAS: 94599-69-6
• 化学式: C₁₀H₂₁N
• 分子量: 155.283
• InChiKey: OTHWQICGKUFKTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• CETP Inhibitors
  申请人：Ali Amjad

  公开号：US20090075979A1

  公开（公告）日：2009-03-19

  Compounds having the structure of Formula (I), including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compounds of Formula (I), B or R 2 is a phenyl group which has an ortho amine or aminomethyl substituent which is further substituted, and the other of B or R 2 is also a cyclic group.

  具有公式（I）结构的化合物，包括该化合物的药物可接受的盐，是CETP抑制剂，并且用于提高HDL胆固醇，降低LDL胆固醇以及治疗或预防动脉粥样硬化。在公式（I）的化合物中，B或R2是具有取代的邻胺基或氨甲基的苯基，另一个B或R2也是一个环状基团。
• Crf Receptor Antagonists and Methods
  申请人：Luo Zhiyong

  公开号：US20070293511A1

  公开（公告）日：2007-12-20

  CRF receptor antagonists are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, such as stroke. The CRF receptor antagonists of this invention have the following structure: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , Y, Ar, and Het are as defined herein. Compositions containing a CRF receptor antagonist in combination with a pharmaceutically acceptable carrier are also disclosed, as well as methods for use of the same.

  本发明揭示了具有治疗多种疾病的用途的CRF受体拮抗剂，包括治疗在恒温动物中表现为CRF过度分泌的疾病，如中风。本发明的CRF受体拮抗剂具有以下结构：包括立体异构体、前药和药学上可接受的盐，其中R1、R2、R3、Y、Ar和Het的定义如本文所述。还揭示了含有CRF受体拮抗剂和药学上可接受的载体的组合物，以及使用它们的方法。
• IONIZABLE LIPIDS AND METHODS OF MANUFACTURE AND USE THEREOF
  申请人：George Mason Research Foundation, Inc.

  公开号：US20220218622A1

  公开（公告）日：2022-07-14

  The invention encompasses novel ionizable lipids compounds and their use in lipid nanoparticles delivery systems that are useful in the delivery of nucleic acids to a mammalian subject that can be included for use, for example, as cancer vaccines, gene editing therapeutics, delivery of nucleic acid (e.g., mRNA) encoding antibodies, vaccines for infectious disease, and protein replacement therapeutics. Additionally, the invention encompasses compositions and therapeutics comprising the ionizable lipids in the lipid nanoparticles and the use of the composition and therapeutics for the preparation of a pharmaceutical composition, especially a vaccine, (e.g., for use in the prophylaxis or treatment of infectious diseases, tumor or cancer diseases, rare diseases, allergies, or autoimmune diseases). The invention encompasses methods of treatment or prophylaxis of the aforementioned diseases.
• US7781426B2
  申请人：——

  公开号：US7781426B2

  公开（公告）日：2010-08-24