2-fluorophenyldiphenylmethane | 436-11-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 2-fluorophenyldiphenylmethane
• 英文别名: (2-Fluor-phenyl)-diphenyl-methan；1-Benzhydryl-2-fluorobenzene
• CAS: 436-11-3
• 化学式: C₁₉H₁₅F
• 分子量: 262.327
• InChiKey: UOTOCVMSHHFVMB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2.2'-Difluor-benzpinakol 在 氢氧化钾 、 碘 、 溶剂黄146 作用下， 生成 2-fluorophenyldiphenylmethane
  参考文献：
  名称：

  Bergmann, Recueil des Travaux Chimiques des Pays-Bas, 1939, vol. 58, p. 863,869

  摘要：

  DOI：

文献信息

• The intramolecular C–F⋯HO hydrogen bond of 2-fluorophenyldiphenylmethanol
  作者：Hiroyuki Takemura、Megumi Kaneko、Katsuya Sako、Tetsuo Iwanaga

  DOI：10.1039/b902203a

  日期：——

  The intramolecular C–F⋯HO hydrogen bond of 2-fluorophenyldiphenylmethanol was observed by X-ray crystallographic analysis and NMR spectroscopy. The features of the spectra were compared to triphenylmethanol (a fluorine-free analog) and 2-fluorophenyldiphenylmethane.

  通过 X 射线晶体学分析和核磁共振光谱观察了 2-氟苯基二苯甲醇的分子内 CâFâ¯HO 氢键。将其光谱特征与三苯基甲醇（一种无氟类似物）和 2-氟苯基二苯甲烷进行了比较。
• Cobler,H., Diss. <Univ. Berlin 1933> S. 44
  作者：Cobler,H.

  DOI：——

  日期：——
• Reduction of Microglia-Mediated Neurotoxicity by KCa3.1 Inhibition
  申请人：Wulff Heike

  公开号：US20130281504A1

  公开（公告）日：2013-10-24

  Methods for deterring microglia-mediated neurotoxicity in a human or non-human animal subjects comprising the step of inhibiting or blocking the intermediate-conductance calcium-activated potassium channel KCa3.1 in microglia, such as in subjects how suffer from neurodegenerative diseases (e.g., Alzeheimer's Disease) or ischemic/anoxic/hypoxic conditions. The inhibition or blocking of the KCa1.3 channels may be accomplished by administering a KCa3.1 inhibiting substance, such as 1-[(2-chlorophenyl)diphenylmethyl]-1H-pyrazole (TRAM-34).
• US7531573B2
  申请人：——

  公开号：US7531573B2

  公开（公告）日：2009-05-12
• [EN] REDUCTION OF MICROGLIA-MEDIATED NEUROTOXICITY BY KCA3.1 INHIBITION<br/>[FR] RÉDUCTION DE LA NEUROTOXICITÉ À MÉDIATION MICROGLIALE PAR L'INHIBITION DE KCA3.1
  申请人：UNIV CALIFORNIA

  公开号：WO2012006117A2

  公开（公告）日：2012-01-12

  Methods for deterring microglia-mediated neurotoxicity in a human or non- human animal subjects comprising the step of inhibiting or blocking the intermediate- conductance calcium-activated potassium channel KCa3.1 in microglia, such as in subjects how suffer from neurodegenerative diseases (e.g., Alzeheimer's Disease) or ischemic/anoxic/hypoxic conditions. The inhibition or blocking of the KCa1.3 channels may be accomplished by administering a KCa3.1 inhibiting substance, such as 1-[(2-chlorophenyl)diphenylmethyl]-1H-pyrazole (TRAM-34).