Triazolo[4,5-b]pyridin-3-yl 2-methylpropanoate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三唑并吡啶类
• 英文名称: Triazolo[4,5-b]pyridin-3-yl 2-methylpropanoate
• 英文别名: triazolo[4,5-b]pyridin-3-yl 2-methylpropanoate
• 化学式: C₉H₁₀N₄O₂
• 分子量: 206.2
• InChiKey: JEYCTPPGSLASQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  69.9
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] BIOLUMINESCENT COMPOSITIONS AND USES THEREOF<br/>[FR] COMPOSITIONS BIOLUMINESCENTES ET LEURS UTILISATIONS
  申请人：ECOLE POLYTECHNIQUE FED DE LAUSANNE EPFL EPFL DAR TTO

  公开号：WO2021152393A1

  公开（公告）日：2021-08-05

  Compositions and methods for non-invasively monitoring the intracellular processing of a biomolecule are provided. The compositions have a novel thio-luciferin moiety which can be conjugated to the biomolecule directly or via a linker such as disulfide bond wherein the luminescent (such as thio-luciferin) or pro-luminescent (such as thio-cyanobenzothiazoles) moiety is released upon reduction of the disulfide bond upon cytosolic internalization.

  提供了用于非侵入性监测生物分子的细胞内处理的组合物和方法。这些组合物具有一种新颖的硫代鲁西非林基团，可以直接或通过二硫键等连接物与生物分子结合，其中发光基团（如硫代鲁西非林）或前发光基团（如硫代氰基苯并噻唑）在胞浆内摄入后通过还原二硫键释放。
• Modified L-asparaginase
  申请人：XL-protein GmbH

  公开号：US10174302B1

  公开（公告）日：2019-01-08

  The disclosure provides a modified protein that is a combination of (i) an L-asparaginase and (ii) one or more (poly)peptide(s), wherein the (poly)peptide consists solely of proline and alanine amino acid residues, and methods of preparation and use thereof.

  本公开提供了一种改性蛋白质，它是(i)L-天冬酰胺酶和(ii)一种或多种（多）肽的组合，其中（多）肽仅由脯氨酸和丙氨酸氨基酸残基组成，并提供了其制备和使用方法。
• Modified L-Asparaginase
  申请人：JAZZ PHARMACEUTICALS IRELAND LTD.

  公开号：US20220056430A1

  公开（公告）日：2022-02-24

  The disclosure provides a modified protein that is a combination of (i) an L-asparaginase and (ii) one or more (poly)peptide(s), wherein the (poly)peptide consists solely of proline and alanine amino acid residues, and methods of preparation and use thereof.