methyl [(diethoxyphosphino)oxy]acetate | 57630-20-3

• 分子结构分类: 有机化合物 - 有机磷化合物 - 亚磷酸三烷基酯
• 英文名称: methyl [(diethoxyphosphino)oxy]acetate
• 英文别名: Phosphorous acid, diethyl methoxycarbonylmethyl ester；methyl 2-diethoxyphosphanyloxyacetate
• CAS: 57630-20-3
• 化学式: C₇H₁₅O₅P
• 分子量: 210.167
• InChiKey: HUAYLDPEEQITGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  methyl [(diethoxyphosphino)oxy]acetate 、 乙醛 生成 巴豆酸甲酯
  参考文献：
  名称：

  MULZER J.; LAMMER O., CHEM. BER., 119,(1986) N 7, 2178-2190

  摘要：

  DOI：

文献信息

• Olefination of methyl (1S,2R,4R)-N-benzoyl-2-formyl-7-azabicyclo[2.2.1]heptane-1-carboxylate, a synthetic approach to new conformationally constrained prolines
  作者：Ana M. Gil、Elena Buñuel、Marı́a D. Dı́az-de-Villegas、Carlos Cativiela

  DOI：10.1016/s0957-4166(03)00200-3

  日期：2003.6

  Wittig olefinations of methyl (1S,2R,4R)-N-benzoyl-2-formyl-7-azabicyclo[2.2.1]heptane-1-carboxylate with several phosphoranes and the Horner-Wittig reaction, using methyl diethylphosphonoacetate, have been tested in order to evaluate their utility in the synthesis of beta-substituted conformationally constrained prolines. Subsequent elaboration of the resulting alkenes has provided proline-amino acid chimeras [combinations of proline with other alpha-amino acids, such as L-norvaline, L-norleucine, L-alpha-(3-phenylpropyl)glycine or L-homoglutamic acid] with the 7-azabicyclo[2.2.1]heptane skeleton in an enantiomerically pure form. (C) 2003 Elsevier Science Ltd. All rights reserved.
• Fluorinated Retinoids via Crossed Aldol Condensation of 1,1,1-Trifluoroacetone
  作者：Dennis Mead、Rhonda Loh、A.E. Asato、R.S.H. Liu

  DOI：10.1016/s0040-4039(00)98859-2

  日期：1985.1
• Efficient Stereo- and Regiocontrolled Alkene Photodimerization through Hydrogen Bond Enforced Preorganization in the Solid State
  作者：Ken S. Feldman、Robert F. Campbell

  DOI：10.1021/jo00112a007

  日期：1995.4
• JAKO, ISABELLE;UIBER, PIERRE;MANN, ANDRE;TADDEI, MAURIZIO;WERMUTH, CAMILL+, TETRAHEDRON LETT., 31,(1990) N, C. 1011-1014
  作者：JAKO, ISABELLE、UIBER, PIERRE、MANN, ANDRE、TADDEI, MAURIZIO、WERMUTH, CAMILL+

  DOI：——

  日期：——
• MULZER J.; LAMMER O., CHEM. BER., 119,(1986) N 7, 2178-2190
  作者：MULZER J.、 LAMMER O.

  DOI：——

  日期：——