2-oxo-N-(pyridin-4-yl)piperidine-3-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-oxo-N-(pyridin-4-yl)piperidine-3-carboxamide
• 英文别名: 2-oxo-N-pyridin-4-ylpiperidine-3-carboxamide
• 化学式: C₁₁H₁₃N₃O₂
• 分子量: 219.24
• InChiKey: AUTULXJWVIWTGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  71.1
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• NOVEL COMPOSITION FOR PREVENTING OR TREATING HEPATITIS C VIRUS, REGULATING PHOSPHORYLATION OF REPLICASE
  申请人：Oh Jong-Won

  公开号：US20140219960A1

  公开（公告）日：2014-08-07

  The present invention relates a novel composition for preventing or treating hepatitis C virus, regulating the phosphorylation of a replicase. More specifically, it is possible to prevent or treat hepatitis C using a novel PRK2 inhibitor discovered through structure modeling, and to prevent or treat hepatitis C, particularly, interferon-insensitive hepatitis C through coadministration of an Hsp90 inhibitor.
• US9249159B2
  申请人：——

  公开号：US9249159B2

  公开（公告）日：2016-02-02
• [EN] NOVEL COMPOSITION FOR PREVENTING OR TREATING HEPATITIS C VIRUS, REGULATING PHOSPHORYLATION OF REPLICASE<br/>[FR] NOUVELLE COMPOSITION POUR LA PRÉVENTION OU LE TRAITEMENT D'UN VIRUS DE L'HÉPATITE C, RÉGULANT LA PHOSPHORYLATION D'UNE RÉPLICASE
  申请人：UNIV YONSEI IACF

  公开号：WO2013002484A1

  公开（公告）日：2013-01-03

  본 발명은 복제효소 인산화를 조절하는 신규 C형 간염 예방 또는 치료용 조성물에 관한 것으로, 보다 상세하게는, 구조모델링을 통해 발굴된 신규한 PRK2 저해제를 통해 C형 간염을 예방 또는 치료할 수 있을 뿐만 아니라 Hsp90 저해제를 병행투여 함으로써 C형 간염, 특히 인터페론 비감수성 C형 간염을 효과적으로 예방 또는 치료할 수 있다.