1-(1-methylpiperidin-1-ium-4-yl)piperidine-3-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(1-methylpiperidin-1-ium-4-yl)piperidine-3-carboxylate
• 化学式: C12H22N2O2
• 分子量: 226.32
• InChiKey: WCJHOGYHNWZGNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• SELECTED CGRP ANTAGONISTS, PROCESSES FOR PREPARING THEM AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS
  申请人：MUELLER Stephan Georg

  公开号：US20110034444A1

  公开（公告）日：2011-02-10

  The present invention relates to the CGRP antagonists of general formula I wherein R 1 , R 2 , R 3 and R 4 are as defined in claim 1 , the tautomers, the isomers, the diastereomers, the enantiomers, the hydrates thereof, the mixtures thereof and the salts thereof and the hydrates of the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, as well as those compounds of general formula I wherein one or more hydrogen atoms are replaced by deuterium, pharmaceutical compositions containing these compounds, their use and processes for preparing them.

  本发明涉及通式I的CGRP拮抗剂，其中R1、R2、R3和R4如权利要求1所定义，其互变异构体、异构体、对映异构体、单纯对映体、其水合物、其混合物及其盐和其盐的水合物，特别是其与无机或有机酸或碱的生理可接受的盐，以及其中一个或多个氢原子被氘取代的通式I的化合物，包含这些化合物的药物组合物，它们的用途和制备它们的过程。