1-Methylsulfanylpiperidin-4-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-Methylsulfanylpiperidin-4-ol
• 英文别名: 1-methylsulfanylpiperidin-4-ol
• 化学式: C₆H₁₃NOS
• 分子量: 147.24
• InChiKey: MJRBOZQRSZAFAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  48.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] HETEROCYCLIC COMPOUNDS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES
  申请人：KYORIN SEIYAKU KK

  公开号：WO2015129927A1

  公开（公告）日：2015-09-03

  Provided herein are compounds of formula I and compositions containing the compounds. The compounds and compositions are useful in the methods of inhibiting the action of ERK5, a BET family protein or both. In certain embodiments, the compounds and compositions are useful in the prevention, amelioration or treatment of a ERK5 -mediated disease, a BET protein-mediated disease or both.

  本文提供了公式I的化合物和含有这些化合物的组合物。这些化合物和组合物在抑制ERK5的作用、BET家族蛋白的作用或两者的方法中是有用的。在某些实施方式中，这些化合物和组合物在预防、改善或治疗ERK5介导的疾病、BET蛋白介导的疾病或两者的方法中是有用的。
• [EN] NON-ATP/CATALYTIC SITE P38 MITOGEN ACTIVATED PROTEIN KINASE INHIBITORS<br/>[FR] INHIBITEURS DE PROTÉINE KINASE ACTIVÉE PAR LE MITOGÈNE P38 DE SITE NON ATP/CATALYTIQUE
  申请人：UNIV MARYLAND

  公开号：WO2021183970A1

  公开（公告）日：2021-09-16

  Compounds that inhibit p38a MAPK protein, and methods of using the same, are provided for treating or preventing diseases such as cancer or inflammatory diseases.

  提供了抑制p38a MAPK蛋白质的化合物，以及使用这些化合物治疗或预防癌症或炎症性疾病的方法。
• Pyrimido-diazepinone kinase scaffold compounds and methods for treating PI3K-mediated disorders
  申请人：DANA-FARBER CANCER INSTITUTE, INC.

  公开号：US11155556B2

  公开（公告）日：2021-10-26

  The present invention relates to use of pyrimido-diazepinone compounds that are able to modulate protein kinases such as PI3K-γ and PI3K-δ, which are members of the Class I Type IA and Class I Type IB family of phosphatidylinositol-4,5-bisphosphate 3-kinases, and the use of such compounds in the treatment of various diseases, disorders or conditions.

  本发明涉及能够调节蛋白激酶如 PI3K-γ 和 PI3K-δ（属于磷脂酰肌醇-4,5-二磷酸 3-激酶的 I 类 IA 型和 I 类 IB 型家族成员）的嘧啶二氮杂卓酮化合物的用途，以及此类化合物在治疗各种疾病、失调或病症中的用途。
• SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20170073330A1

  公开（公告）日：2017-03-16

  The present invention provides compounds of Formula (I): or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikrein which may be used as medicaments.
• PYRIMIDO-DIAZEPINON KINASE SCAFFOLD COMPOUNDS AND METHODS FOR TREATING P13K-MEDIATED DISORDERS
  申请人：DANA-FARBER CANCER INSTITUTE, INC.

  公开号：US20190106424A1

  公开（公告）日：2019-04-11

  The present invention relates to use of pyrimido-diazepinone compounds that are able to modulate protein kinases such as PI3K-γ and PI3K-δ, which are members of the Class I Type IA and Class I Type IB family of phosphatidylinositol-4,5-bisphosphate 3-kinases, and the use of such compounds in the treatment of various diseases, disorders or conditions.