[2-(2-{2-[2-(11-tritylsulfanyl-undecyloxy)ethoxy]ethoxy}ethoxy)ethoxy]acetic acid ethyl ester | 769931-25-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: [2-(2-{2-[2-(11-tritylsulfanyl-undecyloxy)ethoxy]ethoxy}ethoxy)ethoxy]acetic acid ethyl ester
• 英文别名: Ethyl 2-[2-[2-[2-[2-(11-tritylsulfanylundecoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetate
• CAS: 769931-25-1
• 化学式: C₄₂H₆₀O₇S
• 分子量: 709.0
• InChiKey: QAUDWBPHAPVPJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.2
• 重原子数：
  50
• 可旋转键数：
  32
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  97.8
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  [2-(2-{2-[2-(11-tritylsulfanyl-undecyloxy)ethoxy]ethoxy}ethoxy)ethoxy]acetic acid ethyl ester 在 lithium hydroxide 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 12.0h， 以97.6%的产率得到[2-(2-{2-[2-(11-tritylsulfanyl-undecyloxy)ethoxy]ethoxy}ethoxy)ethoxy]acetic acid
  参考文献：
  名称：

  Arrays for the Combinatorial Exploration of Cell Adhesion

  摘要：

  A new method for the fabrication of arrays of self-assembled monolayers (SAMs) of alkane thiols (ATs) on gold to combinatorially assay surfaces for cell adhesion is reported. A fluorous SAM, which is both cytophobic and solvophobic, was used as the background between the array features. The resulting solvophobic background permits the application of an assembly after conjugation strategy for fabrication. SAMs containing mixtures of ATs and peptide-terminated ATs were generated. Multiple cell types demonstrated differential and specific binding to these surfaces. Additionally, pluripotent human embryonic stem cells proliferated on surfaces generated by this method.

  DOI：

  10.1021/ja0474291
• 作为产物：
  描述：

  [2-(2-{2-[2-(11-acetylsulfanyl-undecyloxy)ethoxy]ethoxy}ethoxy)ethoxy]acetic acid ethyl ester 在 盐酸 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 12.0h， 生成 [2-(2-{2-[2-(11-tritylsulfanyl-undecyloxy)ethoxy]ethoxy}ethoxy)ethoxy]acetic acid ethyl ester
  参考文献：
  名称：

  Arrays for the Combinatorial Exploration of Cell Adhesion

  摘要：

  A new method for the fabrication of arrays of self-assembled monolayers (SAMs) of alkane thiols (ATs) on gold to combinatorially assay surfaces for cell adhesion is reported. A fluorous SAM, which is both cytophobic and solvophobic, was used as the background between the array features. The resulting solvophobic background permits the application of an assembly after conjugation strategy for fabrication. SAMs containing mixtures of ATs and peptide-terminated ATs were generated. Multiple cell types demonstrated differential and specific binding to these surfaces. Additionally, pluripotent human embryonic stem cells proliferated on surfaces generated by this method.

  DOI：

  10.1021/ja0474291

文献信息

• Defined surfaces of self-assembled monolayers and stem cells
  申请人：Kiessling L. Laura

  公开号：US20070207543A1

  公开（公告）日：2007-09-06

  A method for the construction of arrays from self-assembling monolayers is described. The arrays have particular utility for the screening of peptides ligands that can foster the growth of cells in culture. This technique has been used to identify peptide ligands that foster the growth of human stem cells, which otherwise require an extracellular matrix in order to grow in an undifferentiated state. This also makes possible an assay to identify other such peptides.
• US8062890B2
  申请人：——

  公开号：US8062890B2

  公开（公告）日：2011-11-22
• Arrays for the Combinatorial Exploration of Cell Adhesion
  作者：Brendan P. Orner、Ratmir Derda、Rachel L. Lewis、James A. Thomson、Laura L. Kiessling

  DOI：10.1021/ja0474291

  日期：2004.9.1

  A new method for the fabrication of arrays of self-assembled monolayers (SAMs) of alkane thiols (ATs) on gold to combinatorially assay surfaces for cell adhesion is reported. A fluorous SAM, which is both cytophobic and solvophobic, was used as the background between the array features. The resulting solvophobic background permits the application of an assembly after conjugation strategy for fabrication. SAMs containing mixtures of ATs and peptide-terminated ATs were generated. Multiple cell types demonstrated differential and specific binding to these surfaces. Additionally, pluripotent human embryonic stem cells proliferated on surfaces generated by this method.