1-(2-Fluoro-6-methylphenyl)piperidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(2-Fluoro-6-methylphenyl)piperidine
• 英文别名: 1-(2-fluoro-6-methylphenyl)piperidine
• 化学式: C₁₂H₁₆FN
• 分子量: 193.26
• InChiKey: RDMHDSCWSDXYBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• 2,4,6,7-TETRAHYDRO-PYRAZOLO[4,3-D]PYRIMIDIN-5-ONE DERIVATIVES AND RELATED COMPOUNDS AS C5A RECEPTOR MODULATORS FOR TREATING VASCULITIS AND INFLAMMATORY DISEASES
  申请人：Idorsia Pharmaceuticals Ltd.

  公开号：US20200369672A1

  公开（公告）日：2020-11-26

  The present invention relates to derivatives of formula (I) wherein Ring A, X, Y, Z, R A , R 1 , R 2 , R 3 and R 4 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as C5a receptor modulators.
• C5A RECEPTOR MODULATORS
  申请人：IDORSIA PHARMACEUTICALS LTD.

  公开号：US20210122736A1

  公开（公告）日：2021-04-29

  The present invention relates to derivatives of formula (I) wherein Ring A, W, X, Y, Z, R 1 , R 2 , R 3 and R 4 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as C5a receptor modulators.