4-(2-methoxybenzyl)piperidin-4-olhydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-(2-methoxybenzyl)piperidin-4-olhydrochloride
• 英文别名: 4-[(2-Methoxyphenyl)methyl]piperidin-4-ol hydrochloride；4-[(2-methoxyphenyl)methyl]piperidin-4-ol;hydrochloride
• 化学式: C₁₃H₁₉NO₂*ClH
• mdl: MFCD28145284
• 分子量: 257.76
• InChiKey: UNVGGORMAQFYHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.538
• 拓扑面积：
  41.5
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
  申请人：Array BioPharma, Inc.

  公开号：US10172845B2

  公开（公告）日：2019-01-08

  Provided herein are compounds of the Formula I: or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X1, X2, X3, X4, Ring D, E, Ra, Rb, n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

  本文提供的是式 I 的化合物： 或其药学上可接受的盐或溶液，其中 A、B、X1、X2、X3、X4、环 D、E、Ra、Rb、n 和 m 具有说明书中给出的含义，它们是 RET 激酶的抑制剂，可用于治疗和预防可用 RET 激酶抑制剂治疗的疾病，包括 RET 相关疾病和失调。
• SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS
  申请人：Array BioPharma, Inc.

  公开号：US20180134703A1

  公开（公告）日：2018-05-17

  Provided herein are compounds of the Formula I: or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X 1 , X 2 , X 3 , X 4 , Ring D, E, R a , R b , n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.