7,7-Dimethyl-hexadecahydro-9,22-dioxa-4a-aza-benzocyclohenicosene-5,6,10,23-tetraone

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯内酰胺
• 英文名称: 7,7-Dimethyl-hexadecahydro-9,22-dioxa-4a-aza-benzocyclohenicosene-5,6,10,23-tetraone
• 英文别名: 4,4-dimethyl-6,19-dioxa-1-azabicyclo[19.4.0]pentacosane-2,3,7,20-tetrone
• 化学式: C₂₄H₃₉NO₆
• 分子量: 437.6
• InChiKey: VUCSBBBCFXBFFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  31
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  90
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• DISEASE RELATED PROTEIN AGGREGATION
  申请人：K.U. Leuven Research and Development

  公开号：EP1747468A2

  公开（公告）日：2007-01-31
• [EN] DISEASE RELATED PROTEIN AGGREGATION<br/>[FR] AGREGATION DE PROTEINES ASSOCIEE A UNE MALADIE
  申请人：LEUVEN K U RES & DEV

  公开号：WO2005109004A2

  公开（公告）日：2005-11-17

  Present invention demonstrates that the members of the FKBP family or FK506 Binding Proteins (FKBPs), more specifically FKBP12 or FKBP52 enhance the aggregation of α-SYN. Moreover, it was found that the effect of FKBP on α-SYN aggregation has its origin in the PPIase activity of the enzyme. Immunophilin ligands, specific inhibitors of the activity of FKBPs, inhibit stimulation of the aggregation of a α-SYN by FKBPs.