1-(4-piperidylphenyl)-3-pyrroline-2,5-dione | 252900-62-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(4-piperidylphenyl)-3-pyrroline-2,5-dione
• 英文别名: 1-(4-Piperidin-1-ylphenyl)pyrrole-2,5-dione
• CAS: 252900-62-2
• 化学式: C₁₅H₁₆N₂O₂
• 分子量: 256.304
• InChiKey: WDVCZWBFCRAQKN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  哌啶 、 1-(4-piperidylphenyl)-3-pyrroline-2,5-dione 以 1,4-二氧六环 为溶剂， 反应 1.0h， 以85.9%的产率得到3-piperidin-1-yl-1-(4-piperidin- 1-yl-phenyl)-pyrrolidine-2,5- dione
  参考文献：
  名称：

  N-Aryl-2-dialkylaminosuccinimides

  摘要：

  Reaction of N-arylmaleimides with an equimolar amount of diethylamine, piperidine, and morpholine afforded the corresponding N-aryl-2-dialkylarninosuccininiides as mixtures of stereoisomers.

  DOI：

  10.1023/b:rujo.0000045189.81688.f3
• 作为产物：
  描述：

  4-(1-哌啶基)苯胺 生成 1-(4-piperidylphenyl)-3-pyrroline-2,5-dione
  参考文献：
  名称：

  MYCOBACTERIAL INHIBITORS

  摘要：

  公开号：

  EP1075261B1

文献信息

• Metal‐ and Solvent‐Free Synthesis of Maleimide Fused Carbazoles from (Indol‐3‐Yl)cyclohexanones and Maleimides
  作者：Fang Fang、Haolin Zheng、Weipeng Li、Guojiang Mao、Shanping Chen、Guo‐Jun Deng

  DOI：10.1002/adsc.202200241

  日期：2022.7.5

  A metal- and solvent-free strategy for the preparation of maleimide-fused carbazoles has been developed. This protocol started from 2-(indol-3-yl)cyclohexanones and maleimides, providing various maleimide-fused carbazoles in 45–90% yields. The present approach was catalyzed by trimethylsulfoxonium iodide and involved a cascade of oxidation, [4+2] annulation, and dehydrogenative aromatization. Moreover

  已经开发了一种用于制备马来酰亚胺稠合咔唑的无金属和无溶剂策略。该协议从 2-(indol-3-yl) 环己酮和马来酰亚胺开始，以 45-90% 的收率提供各种马来酰亚胺融合咔唑。本方法由三甲基碘化亚砜催化，涉及级联氧化、[4+2] 环化和脱氢芳构化。此外，这些马来酰亚胺稠合咔唑产物可以进一步转化为其他多环芳烃。
• Electrocatalytic ring-opening dihydroalkoxylation of <i>N</i>-aryl maleimides with alcohols under metal- and oxidant-free conditions
  作者：Zhang Zhang、Ying-Chun Wang、Hai-Tao Tang、Ying-Ming Pan、Xiu-Jin Meng

  DOI：10.1039/d3ob00178d

  日期：——

  The electrocatalytic ring-opening dihydroalkoxylation of N-aryl maleimides with alcohols under metal- and oxidant-free conditions is described. This electrochemical process consists of anodic single-electron transfer oxidation, cathodic radical reduction, rearrangement-ring cleavage and nucleophilic addition cascade, which employs tetrabutylammonium bromide not only as a redox catalyst but also as

  描述了在无金属和无氧化剂的条件下，N-芳基马来酰亚胺与醇的电催化开环二氢烷氧基化反应。该电化学过程由阳极单电子转移氧化、阴极自由基还原、重排环裂解和亲核加成级联组成，采用四丁基溴化铵作为氧化还原催化剂和高效支持电解质，提供了一种实用且环保的方法。开环双功能化产物的途径。
• MYCOBACTERIAL INHIBITORS
  申请人：AstraZeneca AB

  公开号：EP1075261B1

  公开（公告）日：2006-04-12
• N-Aryl-2-dialkylaminosuccinimides
  作者：O. A. Kolyamshin、V. A. Danilov

  DOI：10.1023/b:rujo.0000045189.81688.f3

  日期：2004.7

  Reaction of N-arylmaleimides with an equimolar amount of diethylamine, piperidine, and morpholine afforded the corresponding N-aryl-2-dialkylarninosuccininiides as mixtures of stereoisomers.