3,4-Dichloro-2,5-thiophenedicarbonyl dichloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 3,4-Dichloro-2,5-thiophenedicarbonyl dichloride
• 英文别名: 3,4-dichlorothiophene-2,5-dicarbonyl chloride
• 化学式: C₆Cl₄O₂S
• 分子量: 277.9
• InChiKey: URRYDCMFOAUXHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  62.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3,4-Dichloro-2,5-thiophenedicarbonyl dichloride 、 硫脲 在 乙醇 作用下， 以 苯 为溶剂， 反应 1.0h， 以to afford 2-(5-carbamimidoylsulfanecarbonyl-3,4-dichlorothiophene-2-carbonyl)isothiourea dihydrochloride as a white solid in 95% yield (0.08 g)的产率得到2-(5-Carbamimidoylsulfanecarbonyl-3,4-dichlorothiophene-2-carbonyl)isothiourea dihydrochloride
  参考文献：
  名称：

  AROMATIC AND HETEROAROMATIC COMPOUNDS USEFUL IN TREATING IRON DISORDERS

  摘要：

  本发明涉及式（I）的化合物，其中m、式（II）、R1、R2和R3如本文所定义，作为立体异构体、对映异构体、互变异构体或其混合物；或其药学上可接受的盐、溶剂或前药，用于治疗铁代谢紊乱。本发明还涉及包含该化合物的制药组合物以及使用该化合物治疗铁代谢紊乱的方法。

  公开号：

  US20100240713A1

文献信息

• Scavenger assisted combinatorial process for preparing libraries of amides, carbamates and sulfonamides
  申请人：ELI LILLY AND COMPANY

  公开号：EP0825164A2

  公开（公告）日：1998-02-25

  This invention relates to a novel solution phase process for the preparation of amide, carbamate, and sulfonamide combinatorial libraries. These libraries have utility for drug discovery and are used to form wellplate components of novel assay kits.

  这项发明涉及一种用于制备酰胺、碳酸酯和磺酰胺组合库的新型溶液相过程。这些库在药物发现中具有实用价值，并用于形成新型检测套件的微孔板组件。
• Methods and apparatus for accelerated orthokeratology
  申请人：——

  公开号：US20010016731A1

  公开（公告）日：2001-08-23

  An accelerated method of orthokeratology includes the steps of softening of the cornea with a softening agent, applying a mold to reshape the cornea to a desired anterior curvature, and rapidly restabilizing or “fixing” the corneal tissues so that the cornea retains its new configuration. A chemical softening agent, such as glutaric anhydride is applied to the cornea to soften the cornea, after which a specially designed mold of predetermined curvature and configuration is applied to the cornea. Slight downward pressure is applied to the mold for a predetermined period of time to re-shape the cornea. The mold is maintained in position while a stabilizing agent, such as a UV light source, is positioned above the mold. The stabilizing agent, i.e. UV light, is applied to the cornea for a predetermined time, wherein the stabilizing agent immediately restabilizes the corneal tissue so that the cornea immediately retains its shape upon removal of the mold. The stabilization process can also be used for patients having already undergone traditional orthokeratology to eliminate the need to continue wearing a retainer to maintain the shape of the cornea.

  角膜矫形术的加速方法包括以下步骤：用软化剂软化角膜，使用模具将角膜重塑成所需的前弧度，并迅速重新稳定或 "固定 "角膜组织，使角膜保持新的形态。在角膜上涂抹化学软化剂（如戊二酸酐）以软化角膜，然后在角膜上涂抹专门设计的具有预定弧度和结构的模具。在预定时间内对模具施加轻微的向下压力，以重新塑形角膜。将稳定剂（如紫外线光源）置于模具上方时，模具将保持在原位。将稳定剂（即紫外线）照射到角膜上，持续预定的时间，其中稳定剂会立即重新稳定角膜组织，使角膜在移除模具后立即保持其形状。稳定过程也可用于已接受传统角膜矫形术的患者，使其无需继续佩戴保持器来保持角膜的形状。
• METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY
  申请人：Ista Pharmaceuticals, Inc.

  公开号：EP1051655A1

  公开（公告）日：2000-11-15
• EP1051655A4
  申请人：——

  公开号：EP1051655A4

  公开（公告）日：2003-03-19
• US5942387A
  申请人：——

  公开号：US5942387A

  公开（公告）日：1999-08-24