[4-[4-[2-[(2,6-Difluorophenyl)methoxy]-1,1,1,3,3,3-hexafluoropropan-2-yl]phenyl]-4-(4-fluorophenyl)sulfonylpiperidin-1-yl]-(oxan-4-yl)methanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: [4-[4-[2-[(2,6-Difluorophenyl)methoxy]-1,1,1,3,3,3-hexafluoropropan-2-yl]phenyl]-4-(4-fluorophenyl)sulfonylpiperidin-1-yl]-(oxan-4-yl)methanone
• 英文别名: [4-[4-[2-[(2,6-difluorophenyl)methoxy]-1,1,1,3,3,3-hexafluoropropan-2-yl]phenyl]-4-(4-fluorophenyl)sulfonylpiperidin-1-yl]-(oxan-4-yl)methanone
• 化学式: C₃₃H₃₀F₉NO₅S
• 分子量: 723.6
• InChiKey: FVZFHZHEMQUFKL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  49
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  81.3
• 氢给体数：
  0
• 氢受体数：
  14

文献信息

• [EN] HETEROCYCLIC SULFONE AS ROR-GAMMA MODULATORS<br/>[FR] SULFONE HÉTÉROCYCLIQUE UTILISÉ EN TANT QUE MODULATEURS DE ROR GAMMA
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2015103510A1

  公开（公告）日：2015-07-09

  Described are RORγ modulators of the formula (I), [INSERT CHEMICAL STRUCTURE HERE] or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune and/or inflammatory disorders.

  描述了公式（I）的RORγ调节剂，或其立体异构体、互变异构体、药学上可接受的盐、溶剂化物或前药，其中所有取代基在此定义。还提供了包含相同化合物的药物组合物。这些化合物和组合物在调节细胞中的RORγ活性的方法以及治疗患有需要调节RORγ活性的疾病或障碍的受试者的方法中非常有用，例如自身免疫和/或炎症性疾病。
• HETEROCYCLIC SULFONE ROR GAMMA MODULATORS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20160326115A1

  公开（公告）日：2016-11-10

  Described are RORγ modulators of the formula (I), [INSERT CHEMICAL STRUCTURE HERE] or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune and/or inflammatory disorders.
• US9637455B2
  申请人：——

  公开号：US9637455B2

  公开（公告）日：2017-05-02