(3-methylcyclopenten-1-yl)oxy-bis(2-methylpropyl)alumane | 138225-46-4

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: (3-methylcyclopenten-1-yl)oxy-bis(2-methylpropyl)alumane
• CAS: 138225-46-4
• 化学式: C₁₄H₂₇AlO
• 分子量: 238.349
• InChiKey: NASPNCSNTYIRAD-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  4.62
• 重原子数：
  16.0
• 可旋转键数：
  6.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  9.23
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  1-chloroethyl phenyl sulfide 、 (3-methylcyclopenten-1-yl)oxy-bis(2-methylpropyl)alumane 在 zinc(II) chloride 作用下， 生成 trans-3-Methyl-2-(1'-phenylthioethyl)cyclopentanone
  参考文献：
  名称：

  Zinc(II)-chloride induced thioalkylation of aluminium enolates; Enantioselective synthesis of estradiol-3-methyl-17-tert-butyl diether

  摘要：

  Zinc(II)-chloride induced thioalkylation of the aluminium enolate 6 generated by conjugate reduction of the enone 5 leads - directly or via its trimethylsilylenol ether 6 - to alkylated hydrindanones 10 which are important intermediates in the synthesis of 19-norsteroids such as the title compound estradiol-3-methyl-17-tert-butyl diether 12.

  DOI：

  10.1016/s0040-4020(01)88282-x

文献信息

• Zinc(II)-chloride induced thioalkylation of aluminium enolates; Enantioselective synthesis of estradiol-3-methyl-17-tert-butyl diether
  作者：Ulrich Groth、Thomas Köhler、Thomas Taapken

  DOI：10.1016/s0040-4020(01)88282-x

  日期：1991.9

  Zinc(II)-chloride induced thioalkylation of the aluminium enolate 6 generated by conjugate reduction of the enone 5 leads - directly or via its trimethylsilylenol ether 6 - to alkylated hydrindanones 10 which are important intermediates in the synthesis of 19-norsteroids such as the title compound estradiol-3-methyl-17-tert-butyl diether 12.