2-[2-(1,1,2,2-Tetramethyl-1-silapropoxy)ethyl]propane-1,3-diol | 396728-63-5

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 2-[2-(1,1,2,2-Tetramethyl-1-silapropoxy)ethyl]propane-1,3-diol
• 英文别名: 2-(2-(tert-butyldimethylsilyloxy)ethyl)propane-1,3-diol；2-[2-[Tert-butyl(dimethyl)silyl]oxyethyl]propane-1,3-diol
• CAS: 396728-63-5
• 化学式: C₁₁H₂₆O₃Si
• 分子量: 234.411
• InChiKey: AALRZKYQMZMJCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.0
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-[2-(1,1,2,2-Tetramethyl-1-silapropoxy)ethyl]propane-1,3-diol 在 四丙基高钌酸铵 、 N-甲基吗啉氧化物 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 4-{[tert-butyl(dimethyl)silyl]oxy}-2-methylidenebutanal
  参考文献：
  名称：

  Synthesis, enzymatic phosphorylation and antiviral activity of acyclic dienyl phosphonate derivatives of guanine

  摘要：

  The synthesis, phosphorylation by guanylate kinase, anti HIV-1 and anti-herpesvirus activity of two acyclic dienyl phosphonate derivatives of guanine are described. (E)-9-(5-phosphono-3-methylene-4-pentenyl)guanine (4) was identified as an excellent substrate of guanylate kinase and a significant inhibitor of HIV-1 replication.

  DOI：

  10.1016/0960-894x(95)00585-h
• 作为产物：
  描述：

  （2-溴乙氧基）-特丁基二甲基硅烷 在 lithium aluminium tetrahydride 、 sodium hydride 作用下， 以 乙醚 为溶剂， 生成 2-[2-(1,1,2,2-Tetramethyl-1-silapropoxy)ethyl]propane-1,3-diol
  参考文献：
  名称：

  Synthesis, enzymatic phosphorylation and antiviral activity of acyclic dienyl phosphonate derivatives of guanine

  摘要：

  The synthesis, phosphorylation by guanylate kinase, anti HIV-1 and anti-herpesvirus activity of two acyclic dienyl phosphonate derivatives of guanine are described. (E)-9-(5-phosphono-3-methylene-4-pentenyl)guanine (4) was identified as an excellent substrate of guanylate kinase and a significant inhibitor of HIV-1 replication.

  DOI：

  10.1016/0960-894x(95)00585-h

文献信息

• [EN] PHOSPHOGLYCERATE KINASE INHIBITORS<br/>[FR] INHIBITEURS DE LA PHOSPHOGLYCÉRATE KINASE
  申请人：ABBOTT LAB

  公开号：WO2012045196A1

  公开（公告）日：2012-04-12

  Disclosed are compounds of formula (I) or pharmaceutical acceptable salts thereof, wherein R1, R2, R3 and R4 are as defined in the description. Disclosed are also the methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as phosphoglycerate kinase.

  揭示了化合物的结构式（I）或其药用可接受的盐，其中R1、R2、R3和R4如描述中所定义。还公开了制备所述化合物的方法，以及含有这些化合物的组合物，这些化合物对抑制磷酸甘油酸激酶等激酶具有用处。
• Synthesis, enzymatic phosphorylation and antiviral activity of acyclic dienyl phosphonate derivatives of guanine
  作者：Jean-François Navé、Patrick J. Casara、Debra L. Taylor、A. Stanley Tyms、Michael Kenny、Serge HalazyS

  DOI：10.1016/0960-894x(95)00585-h

  日期：1996.1

  The synthesis, phosphorylation by guanylate kinase, anti HIV-1 and anti-herpesvirus activity of two acyclic dienyl phosphonate derivatives of guanine are described. (E)-9-(5-phosphono-3-methylene-4-pentenyl)guanine (4) was identified as an excellent substrate of guanylate kinase and a significant inhibitor of HIV-1 replication.