2-Propionamido-thiazolin | 89600-75-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: 2-Propionamido-thiazolin
• 英文别名: N-(4,5-dihydro-thiazol-2-yl)-propionamide；N-(4,5-dihydro-1,3-thiazol-2-yl)propanamide
• CAS: 89600-75-9
• 化学式: C₆H₁₀N₂OS
• mdl: MFCD01410165
• 分子量: 158.224
• InChiKey: ZRVQMYBTULSIGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  66.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• 15.BETA.-[3-PROPANAMIDO]-SUBSTITUTED ESTRA-1,3,5(10)-TRIEN-17-ONE COMPOUNDS AND THEIR 17-OXIMES FOR USE IN INHIBITION OF 17.BETA.-HYDROXYSTEROID DEHYDROGENASES
  申请人：Forendo Pharma Ltd

  公开号：EP3634975A2

  公开（公告）日：2020-04-15
• [EN] THERAPEUTICALLY ACTIVE STEROIDAL DERIVATIVES<br/>[FR] DÉRIVÉS STÉROÏDIENS THÉRAPEUTIQUEMENT ACTIFS
  申请人：FORENDO PHARMA LTD

  公开号：WO2018224736A2

  公开（公告）日：2018-12-13

  The invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof (I) wherein R1 to R4 are as defined in the claims. The invention further relates to their use as inhibitors of 17β-HSD1 and in treatment or prevention of steroid hormone de- pendent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of the 17β-HSD1 enzyme and/or requiring the lowering of the endogenous estradiol concentration. The present invention also relates to the preparation of the aforementioned compounds and to pharmaceutical compositions comprising as an active ingredient(s) one or more of the afore mentioned compounds or pharmaceutically acceptable salts thereof.