(4S)-4-tert-butyl-2-[1-[(4S)-4-tert-butyl-4,5-dihydro-1,3-oxazol-2-yl]propyl]-4,5-dihydro-1,3-oxazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: (4S)-4-tert-butyl-2-[1-[(4S)-4-tert-butyl-4,5-dihydro-1,3-oxazol-2-yl]propyl]-4,5-dihydro-1,3-oxazole
• 化学式: C₁₇H₃₀N₂O₂
• 分子量: 294.4
• InChiKey: ZVGBNZSVPDXNBV-CHWSQXEVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  43.2
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• DEPROTECTION METHOD AND RESIN REMOVAL METHOD IN SOLID-PHASE REACTION FOR PEPTIDE COMPOUND OR AMIDE COMPOUND, AND METHOD FOR PRODUCING PEPTIDE COMPOUND
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：EP3889164A1

  公开（公告）日：2021-10-06

  The present inventors found that peptide compounds/amide compounds in which the protecting groups of interest are removed and/or which are removed from resins for solid-phase synthesis can be produced without main chain damage by contacting starting peptide compounds/amide compounds with silylating agents.

  本发明者发现，通过将起始肽化合物/酰胺化合物与硅烷化剂接触，可以生产出去除相关保护基团和/或从固相合成树脂中去除保护基团和/或从固相合成树脂中去除保护基团和/或从固相合成树脂中去除保护基团和/或从固相合成树脂中去除保护基团的肽化合物/酰胺化合物，而不会对主链造成破坏。
• METHODS OF SELECTIVE ARYL- AND HETEROARYL-NITROGEN BOND FORMATION
  申请人：Janssen Sciences Ireland Unlimited Company

  公开号：US20200079790A1

  公开（公告）日：2020-03-12

  The disclosure is directed to methods of preparing compounds having the formula (I-A) and compounds involved in the preparation of such compounds.
• [EN] METHODS OF SELECTIVE ARYL- AND HETEROARYL-NITROGEN BOND FORMATION<br/>[FR] PROCÉDÉS DE FORMATION SÉLECTIVE DE LIAISON ARYLE- ET HÉTÉROARYLE-AZOTE
  申请人：JANSSEN SCIENCES IRELAND UC

  公开号：WO2018170220A1

  公开（公告）日：2018-09-20

  The disclosure is directed to methods of preparing compounds having the formula (I-A) and compounds involved in the preparation of such compounds.