N-Isopropyl-4,5-dihydrothiazol-2-amine | 76495-24-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: N-Isopropyl-4,5-dihydrothiazol-2-amine
• 英文别名: N-propan-2-yl-4,5-dihydro-1,3-thiazol-2-amine
• CAS: 76495-24-4
• 化学式: C₆H₁₂N₂S
• mdl: MFCD00718337
• 分子量: 144.24
• InChiKey: QDWGKCWXXKFJBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  49.7
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Potassium Channel Inhibitors
  申请人：Dinsmore J. Christoph

  公开号：US20080090794A1

  公开（公告）日：2008-04-17

  The present invention relates to compounds having the structure useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.

  本发明涉及具有以下结构的化合物，用作钾通道抑制剂，用于治疗心律失常等。
• Azaindenoisoquinoline compounds and uses thereof
  申请人：Purdue Research Foundation

  公开号：US10875860B2

  公开（公告）日：2020-12-29

  Tyrosyl-DNA Phosphodiesterases 1 and 2 (Tdp1 and Tdp2) can repair damaged DNA resulting from topoisomerase inhibitors (e.g. Top1) and a variety of other DNA-damaging agents. 7-Azaindenoisoquinolines that are inhibitors of each of Top1, Tdp1 and Tdp2 are disclosed. Also described are methods for preparing azaindenoisoquinoline and methods for treating patients of a cancer using the disclosed azaindenoisoquinoline compounds or a pharmaceutical formulation thereof.

  酪氨酰-DNA 磷酸二酯酶 1 和 2（Tdp1 和 Tdp2）可以修复拓扑异构酶抑制剂（如 Top1）和其他多种 DNA 损伤剂造成的受损 DNA。7-Azaindenoisoquinolines 是 Top1、Tdp1 和 Tdp2 的抑制剂。还描述了制备偶氮亚氨基异喹啉的方法和使用所公开的偶氮亚氨基异喹啉化合物或其药物制剂治疗癌症患者的方法。
• METHODS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH ANGIOGENESIS USING A VASCULAR ADHESION PROTEIN-1 (VAP 1) INHIBITOR
  申请人：Hafezi-Moghadam Ali

  公开号：US20090170770A1

  公开（公告）日：2009-07-02

  The invention relates generally to methods and compositions for treating conditions associated with angiogenesis, and, more specifically, the invention relates to methods and compositions for treating conditions associated with angiogenesis using vascular adhesion protein-1 (VAP-1) inhibitors. The invention also relates to methods and compositions for treating conditions associated with lymphangiogenesis using VAP-1 inhibitors.
• METHODS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH ANGIOGENESIS USING A VASCULAR ADHESION PROTEIN-1 (VAP-1) INHIBITOR
  申请人：MASSACHUSETTS EYE & EAR INFIRMARY

  公开号：US20190076406A1

  公开（公告）日：2019-03-14

  The invention relates generally to methods and compositions for treating conditions associated with angiogenesis, and, more specifically, the invention relates to methods and compositions for treating conditions associated with angiogenesis using vascular adhesion protein-1 (VAP-1) inhibitors. The invention also relates to methods and compositions for treating conditions associated with lymphangiogenesis using VAP-1 inhibitors.
• AZAINDENOISOQUINOLINE COMPOUNDS AND USES THEREOF
  申请人：Purdue Research Foundation

  公开号：US20200095243A1

  公开（公告）日：2020-03-26

  Tyrosyl-DNA Phosphodiesterases 1 and 2 (Tdp1 and Tdp2) can repair damaged DNA resulting from topoisomerase inhibitors (e.g. Top1) and a variety of other DNA-damaging agents. 7-Azaindenoisoquinolines that are inhibitors of each of Top1, Tdp1 and Tdp2 are disclosed. Also described are methods for preparing azaindenoisoquinoline and methods for treating patients of a cancer using the disclosed azaindenoisoquinoline compounds or a pharmaceutical formulation thereof.