3-(1-Benzyl-4-hydroxypiperidin-4-yl)dihydrofuran-2(3H)-one | 28532-91-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-(1-Benzyl-4-hydroxypiperidin-4-yl)dihydrofuran-2(3H)-one
• 英文别名: 3-(1-benzyl-4-hydroxypiperidin-4-yl)oxolan-2-one
• CAS: 28532-91-4
• 化学式: C₁₆H₂₁NO₃
• 分子量: 275.34
• InChiKey: LSABJPIDIAERGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• THE USE OF CD4-BINDING SMALL MOLECULES TO INHIBIT HIV INFECTION
  申请人：THOMAS JEFFERSON UNIVERSITY

  公开号：EP1100500A1

  公开（公告）日：2001-05-23
• [EN] THE USE OF CD4-BINDING SMALL MOLECULES TO INHIBIT HIV INFECTION<br/>[FR] UTILISATION DE PETITES MOLECULES A LIAISON CD-4 POUR INHIBER L'INFECTION PAR LE VIH
  申请人：UNIV JEFFERSON

  公开号：WO2000004903A1

  公开（公告）日：2000-02-03

  A method of inhibiting HIV-1 infection is provided that comprises administering to a subject an effective amount of an active compound having a molecular weight of between 200 daltons and 650 daltons. At a concentration of not more than 100 νM, compounds useful in the practice of the invention inhibit greater than 50 % of the binding of gp120 to CD4. Preferred compounds are further characterized in that they inhibit less than 10 % of the binding of human CD4-expressing, CD4-transfected COS cells to Raji cells.