Methyl 3-(2-chloroethylsulfonyl)propanoate

• 分子结构分类: 有机化合物 - 有机硫化合物 - 磺酰类
• 英文名称: Methyl 3-(2-chloroethylsulfonyl)propanoate
• 化学式: C₆H₁₁ClO₄S
• mdl: MFCD00183114
• 分子量: 214.67
• InChiKey: RYFXRNARKYBQNB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  68.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• NOVEL HYDROPHILIC LINKERS AND LIGAND-DRUG CONJUGATES THEREOF
  申请人：HANGZHOU DAC BIOTECH CO., LTD.

  公开号：US20190125894A1

  公开（公告）日：2019-05-02

  Hydrophilic linkers are useful for linking drugs to cell-binding ligands in ligand-drug conjugates, such as antibody-drug conjugates. The ligand-drug conjugate includes a cell-binding ligand capable of binding to a particular cell population, and a drug connected to the ligand by a hydrophilic linker. The hydrophilic linker includes one or more hydrophilic groups that render the linker hydrophilic. The hydrophilic linker may also include functional groups at the two termini for coupling to the drug and the cell-binding ligand respectively.

  亲水性连接剂对于将药物与细胞结合配体在配体-药物共轭物中连接起来是很有用的，比如抗体-药物共轭物。这种配体-药物共轭物包括一个能够结合到特定细胞群的细胞结合配体，以及一个通过亲水性连接剂连接到配体的药物。亲水性连接剂包括一个或多个使连接剂具有亲水性的亲水性基团。亲水性连接剂还可能在两个末端包括功能基团，分别用于与药物和细胞结合配体进行偶联。
• Hydrophilic linkers and ligand-drug conjugates thereof
  申请人：HANGZHOU DAC BIOTECH CO., LTD.

  公开号：US10456479B2

  公开（公告）日：2019-10-29

  Hydrophilic linkers are useful for linking drugs to cell-binding ligands in ligand-drug conjugates, such as antibody-drug conjugates. The ligand-drug conjugate includes a cell-binding ligand capable of binding to a particular cell population, and a drug connected to the ligand by a hydrophilic linker. The hydrophilic linker includes one or more hydrophilic groups that render the linker hydrophilic. The hydrophilic linker may also include functional groups at the two termini for coupling to the drug and the cell-binding ligand respectively.

  亲水连接体可用于连接配体-药物共轭物（如抗体-药物共轭物）中的药物与细胞结合配体。配体-药物共轭物包括能与特定细胞群结合的细胞结合配体，以及通过亲水连接体与配体连接的药物。亲水连接体包括一个或多个亲水基团，使连接体具有亲水性。亲水连接体的两个末端还可包括分别与药物和细胞结合配体偶联的官能团。