5,5,5-Triphenylpentanoicacid | 33885-03-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 5,5,5-Triphenylpentanoicacid
• 英文别名: 5,5,5-triphenyl-valeric acid；5,5,5-Triphenyl-valeriansaeure；5,5,5-Triphenylpentanoic acid
• CAS: 33885-03-9
• 化学式: C₂₃H₂₂O₂
• 分子量: 330.426
• InChiKey: MSIAYOAPKLPCMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 5,5,5-Triphenylpentanoicacid 生成 Methyl-5,5,5-triphenylpentanoat
  参考文献：
  名称：

  Carbanions. XI. Reactions of 4-chloro-1,1,1-triphenylbutane, 5-chloro-1,1,1-triphenylpentane, and 1,1,1-triphenylethane with alkali metals. 1,4 and 1,5 Migration of phenyl

  摘要：

  DOI：

  10.1021/jo00974a001
• 作为产物：
  描述：

  4-氯-1,1,1-三苯基-丁烷 在 氢氧化钾 、 sodium iodide 作用下， 以 乙二醇 为溶剂， 生成 5,5,5-Triphenylpentanoicacid
  参考文献：
  名称：

  Carbanions. XI. Reactions of 4-chloro-1,1,1-triphenylbutane, 5-chloro-1,1,1-triphenylpentane, and 1,1,1-triphenylethane with alkali metals. 1,4 and 1,5 Migration of phenyl

  摘要：

  DOI：

  10.1021/jo00974a001

文献信息

• Reagents And Methods for Detecting Protein Lysine 3-Hydroxybutyrylation
  申请人：PTM Biolabs, Inc.

  公开号：US20150051093A1

  公开（公告）日：2015-02-19

  The invention provides an isolated peptide comprising a lysine 3-hydroxybutyrylation site, a lysine 3-hydroxybutyrylation specific affinity reagent that specifically binds to the peptide, and a method for detecting protein lysine 3-hydroxybutyrylation in a sample using the reagent.

  该发明提供了一种孤立的肽，包括一个赖氨酸3-羟基丁酰化位点，一个赖氨酸3-羟基丁酰化特异性亲和试剂，该试剂可以特异性地结合到该肽，并且提供了一种使用该试剂检测样品中蛋白质赖氨酸3-羟基丁酰化的方法。
• Reagents and methods for detecting protein lysine 3-hydroxybutyrylation
  申请人：PTM BIO LLC

  公开号：US11385240B2

  公开（公告）日：2022-07-12

  The invention provides an isolated peptide comprising a lysine 3-hydroxybutyrylation site, a lysine 3-hydroxybutyrylation specific affinity reagent that specifically binds to the peptide, and a method for detecting protein lysine 3-hydroxybutyrylation in a sample using the reagent.

  本发明提供了一种包含赖氨酸 3-羟基丁酰化位点的分离肽、一种与该肽特异性结合的赖氨酸 3-羟基丁酰化特异性亲和试剂，以及一种使用该试剂检测样品中蛋白质赖氨酸 3-羟基丁酰化的方法。
• Alkylation of Cyclopropyl Phenyl Ketone
  作者：Frank J. Piehl、Weldon G. Brown

  DOI：10.1021/ja01116a040

  日期：1953.10
• Triphenylmethylamides (TPMAs): Structure–activity relationship of compounds that induce apoptosis in melanoma cells
  作者：Rahul Palchaudhuri、Paul J. Hergenrother

  DOI：10.1016/j.bmcl.2008.07.128

  日期：2008.11

  Triphenylmethylamides (TPMAs) have been previously identified as compounds that arrest cells in the G1-phase of the cell cycle and induce apoptotic death in melanoma cell lines in culture. Here we report the synthesis of a series of TPMA derivatives, allowing the structure-activity relationship of this class of molecules to be established. Several new compounds have been identified that induce death in UACC-62 and SK-MEL-5 human melanoma cell lines, including a compound with enhanced aqueous solubility. (C) 2008 Elsevier Ltd. All rights reserved.
• REAGENTS AND METHODS FOR DETECTING PROTEIN LYSINE 3-HYDROXYBUTYRYLATION
  申请人：PTM BIO LLC

  公开号：US20190331695A1

  公开（公告）日：2019-10-31

  The invention provides an isolated peptide comprising a lysine 3-hydroxybutyrylation site, a lysine 3-hydroxybutyrylation specific affinity reagent that specifically binds to the peptide, and a method for detecting protein lysine 3-hydroxybutyrylation in a sample using the reagent.