4-Amino-4-hydroxymethyl-1-t-butylpiperidin | 33554-21-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-Amino-4-hydroxymethyl-1-t-butylpiperidin
• 英文别名: (4-amino-1-tert-butyl-piperidin-4-yl)-methanol；(4-Amino-1-tert-butylpiperidin-4-yl)methanol
• CAS: 33554-21-1
• 化学式: C₁₀H₂₂N₂O
• 分子量: 186.297
• InChiKey: TXQUYZIEBHBUBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• ENANTIOMERICALLY PURE ADAMANTANE CARBOXAMIDES FOR THE TREATMENT OF FILOVIRUS INFECTION
  申请人：Arisan Therapeutics, Inc.

  公开号：US20210171521A1

  公开（公告）日：2021-06-10

  The compounds of the invention as shown by general structure I, as shown below, are effective in treating filovirus infections. X is selected from the group consisting of O and H; R 1 is selected from (C 6 to C 10 ) aryl and (C 2 to C 9 ) heteroaryl, and R 2 is selected from (C 1 to C 10 ) alkyl, (C 1 to C 10 ) alkenyl, (C 1 to C 10 ) alkynyl, (C 3 to C 10 ) cycloalkyl, and (C 5 to C 10 ) cycloalkenyl, and NR 3a R 3b is defined in the specification. These compounds are effective in treating filovirii infections including Ebolavirus and Marburg virus.
• PROTEIN TYROSINE PHOSPHATASE INHIBITORS
  申请人：Array BioPharma Inc.

  公开号：US20210380582A1

  公开（公告）日：2021-12-09

  Compounds of Formula Ia or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases. Methods of using compounds of Formula Ia or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed