2-[(2S,3S,4R)-1-[5-[(3R,4R)-1-(5-ethoxy-2-fluorophenyl)-3-methylpiperidin-4-yl]oxypyrazin-2-yl]-4-methoxy-3-methylpyrrolidin-2-yl]acetic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-[(2S,3S,4R)-1-[5-[(3R,4R)-1-(5-ethoxy-2-fluorophenyl)-3-methylpiperidin-4-yl]oxypyrazin-2-yl]-4-methoxy-3-methylpyrrolidin-2-yl]acetic acid
• 化学式: C₂₆H₃₅FN₄O₅
• 分子量: 502.6
• InChiKey: NDAAJBSYACYTRF-LCHGUAGMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  36
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  97.2
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• Pyrrolidine GPR40 modulators for the treatment of diseases such as diabetes
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US10017497B2

  公开（公告）日：2018-07-10

  The present invention provides compounds of Formula (I) or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, or a solvate thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.

  本发明提供了式(I)化合物或其立体异构体、同分异构体、药学上可接受的盐或其溶液，其中所有变量如本文所定义。这些化合物是可用作药物的 GPR40 G 蛋白偶联受体调节剂。
• PYRROLIDINE GPR40 MODULATORS FOR THE TREATMENT OF DISEASES SUCH AS DIABETES
  申请人：Bristol-Myers Squibb Company

  公开号：EP3140297A1

  公开（公告）日：2017-03-15
• [EN] PYRROLIDINE GPR40 MODULATORS FOR THE TREATMENT OF DISEASES SUCH AS DIABETES<br/>[FR] COMPOSÉS PYRROLIDINE MODULATEURS DE GPR40 POUR LE TRAITEMENT DE MALADIES TELLES QUE LE DIABÈTE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2015171733A1

  公开（公告）日：2015-11-12

  The present invention provides compounds of Formula (I) or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, or a solvate thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.