(1R)-1-(1-benzylpiperidin-4-yl)ethanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (1R)-1-(1-benzylpiperidin-4-yl)ethanol
• 化学式: C₁₄H₂₁NO
• 分子量: 219.32
• InChiKey: APLPFTYDMDHGAR-GFCCVEGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY
  申请人：CHIESI FARMACEUTICI S.P.A.

  公开号：US20180016267A1

  公开（公告）日：2018-01-18

  Compounds of formula I defined herein act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for the prevention and/or treatment of broncho-obstructive or inflammatory diseases.

  本处定义的I式化合物既作为肌肉收缩受体拮抗剂，又作为β2肾上腺素受体激动剂，可用于预防和/或治疗支气管阻塞或炎症性疾病。
• Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
  申请人：CHIESI FARMACEUTICI S.P.A.

  公开号：US10196386B2

  公开（公告）日：2019-02-05

  Compounds of formula I defined herein act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for the prevention and/or treatment of broncho-obstructive or inflammatory diseases.

  本文定义的式 I 化合物既是毒蕈碱受体拮抗剂，又是β2 肾上腺素能受体激动剂，可用于预防和/或治疗支气管阻塞性或炎症性疾病。
• HYDROXYQUINOLINONE COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY
  申请人：Chiesi Farmaceutici S.p.A.

  公开号：EP3484879B1

  公开（公告）日：2020-12-30
• [EN] HYDROXYQUINOLINONE COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY<br/>[FR] COMPOSÉS D'HYDROXYQUINOLINONE AYANT UNE ACTIVITÉ D'ANTAGONISTE DES RÉCEPTEURS MUSCARINIQUES ET D'AGONISTE DES RÉCEPTEURS ADRÉNERGIQUES BÊTA2
  申请人：CHIESI FARM SPA

  公开号：WO2018011090A1

  公开（公告）日：2018-01-18

  The present invention relates to compounds acting both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists, to processes for their preparation, to compositions comprising them, to therapeutic uses and combinations with other pharmaceutical active ingredients.