8-甲基-8-氮杂双环[3.2.1]辛-6-烯-3-醇盐酸盐 | 99709-24-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 8-甲基-8-氮杂双环[3.2.1]辛-6-烯-3-醇盐酸盐
• 英文名称: 8-methyl-8-azabicyclo[3.2.1]oct-6-en-3-ol Hydrochloride
• 英文别名: 8-methyl-8-azabicyclo[3.2.1]oct-6-en-3-ol;hydrochloride
• CAS: 99709-24-7
• 化学式: C8H14ClNO
• 分子量: 175.65
• InChiKey: KQXIXVUWSVWODX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  23.5
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090

文献信息

• Modulators of acetylcholine receptors
  申请人：Astles Charles Peter

  公开号：US20050182088A1

  公开（公告）日：2005-08-18

  The present invention relates to compounds that modulate neurotransmission by promoting the release of neurotransmitters such as acetylcholine, dopamine and norepinephrine. More particularly, the present invention relates to thio-bridged aryl compounds that are capable of modulating acetylcholine receptors and pharmaceutical compositions comprising such compounds. The compounds disclosed are useful for the treatment of dysfunctions of the central and autonomic nervous systems.

  本发明涉及化合物，通过促进乙酰胆碱、多巴胺和去甲肾上腺素等神经递质的释放来调节神经递质。更具体地，本发明涉及能够调节乙酰胆碱受体的硫桥联芳基化合物和包含此类化合物的药物组合物。所披露的化合物对中枢神经系统和自主神经系统功能障碍的治疗具有用处。
• MODULATORS OF ACETYLCHOLINE RECEPTORS
  申请人：ELI LILLY AND COMPANY

  公开号：EP1472248A1

  公开（公告）日：2004-11-03
• US7148236B2
  申请人：——

  公开号：US7148236B2

  公开（公告）日：2006-12-12
• [EN] MODULATORS OF ACETYLCHOLINE RECEPTORS<br/>[FR] MODULATEURS DE RECEPTEURS DE L'ACETYLCHOLINE
  申请人：LILLY CO ELI

  公开号：WO2003062235A1

  公开（公告）日：2003-07-31

  The present invention relates to compounds that modulate neurotransmission by promoting the release of neurotransmitters such as acetylcholine, dopamine and norepinephrine. More particularly, the present invention relates to thio-bridged aryl compounds that are capable of modulating acetylcholine receptors and pharmaceutical compositions comprising such compounds. The compounds disclosed are useful for the treatment of dysfunctions of the central and autonomic nervous systems.