4-[[3,5-Bis(trifluoromethyl)phenyl]methyl]piperidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-[[3,5-Bis(trifluoromethyl)phenyl]methyl]piperidine
• 化学式: C₁₄H₁₅F₆N
• 分子量: 311.27
• InChiKey: BWDDICGBUOKWOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Neurotherapeutic azole compounds
  申请人：Choi Moon Yong

  公开号：US20060258718A1

  公开（公告）日：2006-11-16

  Azole compounds containing carbamoyl group and pharmaceutically useful salts thereof are described. The compounds are effective anticonvulsants which are used in the treatment of disorders of the central nervous system, especially as anxiety, depression, convulsion, epilepsy, migraine, bipolar disorder, drug abuse, smoking, ADHD, obesity, sleep disorder, neuropathic pain, stroke, cognitive impairment, neurodegeneration, stroke and muscle spasm.

  本文介绍了含有氨基甲酰基的唑类化合物及其药用盐。这些化合物是有效的抗癫痫药物，可用于治疗中枢神经系统疾病，特别是焦虑、抑郁、惊厥、癫痫、偏头痛、双相障碍、药物滥用、吸烟、注意力缺陷多动障碍、肥胖症、睡眠障碍、神经痛、中风、认知障碍、神经退行性疾病、中风和肌肉痉挛。
• HETEROCYCLIC COMPOUND
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP3438109A1

  公开（公告）日：2019-02-06

  The present invention provides a compound having an MAGL inhibitory action, and useful as an agent for the prophylaxis or treatment of neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, traumatic brain injury, glaucoma, multiple sclerosis etc.), anxiety disorder, pains (e.g., inflammatory pain, cancerous pain, neurogenic pain etc.), epilepsy, depression and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

  本发明提供了一种具有MAGL抑制作用的化合物，可作为预防或治疗神经退行性疾病（如阿尔茨海默病、帕金森病、亨廷顿病、肌萎缩性脊髓侧索硬化症、脑外伤、青光眼、多发性硬化症等）、焦虑症、疼痛（如炎性疼痛、癌性疼痛、神经源性疼痛等）、癫痫、抑郁症等的药物。 本发明涉及一种由式（I）代表的化合物： 其中各符号如说明书中所定义，或其盐。
• NEUROTHERAPEUTIC AZOLE COMPOUNDS
  申请人：SK Holdings Co., Ltd.

  公开号：EP1879873A1

  公开（公告）日：2008-01-23
• US7598279B2
  申请人：——

  公开号：US7598279B2

  公开（公告）日：2009-10-06
• [EN] NEUROTHERAPEUTIC AZOLE COMPOUNDS<br/>[FR] COMPOSES AZOLE NEUROTHERAPEUTIQUES
  申请人：SK CORP

  公开号：WO2006112685A1

  公开（公告）日：2006-10-26

  [EN] Azole compounds containing carbamoyl group and pharmaceutically useful salts thereof are described. The compounds are effective anticonvulsants which are used in the treatment of disorders of the central nervous system, especially as anxiety, depression, convulsion, epilepsy, migraine, bipolar disorder, drug abuse, smoking, ADHD, obesity, sleep disorder, neuropathic pain, stroke, cognitive impairment, neurodegeneration, stroke and muscle spasm.
  [FR] Composés azole contenant un groupe carbamoyle et sels pharmaceutiquement utiles correspondants, efficaces comme anticonvulsifs dans le traitement des troubles du système nerveux central, en particulier l'anxiété, la dépression, les convulsions, l'épilepsie, la migraine, les troubles bipolaires, l'abus de drogues, l'abus du tabac, le trouble d'hyperactivité avec déficit de l'attention, l'obésité, les troubles du sommeil, la douleur neuropathique, la déficience cognitive, la neurodégénérescence, l'accident vasculaire cérébral et les spasmes musculaires.