3-Methyl-1-(2-methylpiperidino)-1-butanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-Methyl-1-(2-methylpiperidino)-1-butanone
• 英文别名: 3-methyl-1-(2-methylpiperidin-1-yl)butan-1-one
• 化学式: C₁₁H₂₁NO
• 分子量: 183.29
• InChiKey: JHSBCXDEYHDBAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] PEPTIDOMIMETIC PROTEASOME INHIBITORS<br/>[FR] INHIBITEURS PEPTIDOMIMÉTIQUES DU PROTÉASOME
  申请人：UNIV CORNELL

  公开号：WO2019075252A1

  公开（公告）日：2019-04-18

  The compounds of the present invention are represented by the following compounds having Formula (I) and Formula (I'): where the substituents R, R1, R3 R4, R', W, X, Y, Z, k, and m are as defined herein and where the substituents R, R1, R2, R3, R4, X, Y, Z, and m are as defined herein. These compounds are used in the treatment of bacterial infections, parasite infections, fungal infections, cancer, immunologic disorders, autoimmune disorders, neurodegenerative diseases and disorders, inflammatory disorders, or muscular dystrophy or for providing immunosuppression for transplanted organs or tissues.

  本发明的化合物由具有式（I）和式（I'）的以下化合物表示：其中取代基R、R1、R3、R4、R'、W、X、Y、Z、k和m如本文所定义，取代基R、R1、R2、R3、R4、X、Y、Z和m如本文所定义。这些化合物用于治疗细菌感染、寄生虫感染、真菌感染、癌症、免疫紊乱、自身免疫性疾病、神经退行性疾病和紊乱、炎症性疾病，或肌肉萎缩症，或用于为移植的器官或组织提供免疫抑制。
• BRIDGED HETEROCYCLIC COMPOUNDS AND METHODS OF USE
  申请人：MEDIVATION TECHNOLOGIES, INC.

  公开号：US20130190303A1

  公开（公告）日：2013-07-25

  This disclosure relates to new compounds that may be used to modulate a histamine receptor in an individual. Novel compounds are described, including new bridged heterocyclic [4,3-b]indole compounds. Pharmaceutical compositions are also provided. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

  本公开涉及可用于调节组织胺受体的新化合物。其中描述了新的桥接杂环[4,3-b]吲哚化合物。还提供了制药组合物，包括含有该化合物的制药组合物。还提供了使用该化合物进行各种治疗应用的方法，包括治疗认知障碍、精神障碍、神经递质介导的障碍和/或神经元障碍。
• FUSED TETRACYCLIC PYRIDO [4,3-B] INDOLE AND PYRIDO [3,4-B] INDOLE DERIVATIVES AND METHODS OF USE
  申请人：Chakravarty Sarvajit

  公开号：US20130210803A1

  公开（公告）日：2013-08-15

  This disclosure is directed to fused tetracyclic pyrido[4,3-b]indoles and pyrido[3,4-b]indoles. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

  本公开涉及熔合四环吡啶[4,3-b]吲哚和吡啶[3,4-b]吲哚。还提供了包含这些化合物的制药组合物，以及使用这些化合物进行多种治疗应用的方法，包括治疗认知障碍、精神障碍、神经递质介导的障碍和/或神经元障碍。
• Peptidomimetic proteasome inhibitors
  申请人：CORNELL UNIVERSITY

  公开号：US11203613B2

  公开（公告）日：2021-12-21

  The compounds of the present invention are represented by the following compounds having Formula (I) and Formula (I′): where the substituents R, R1, R3 R4, R′, W, X, Y, Z, k, and m are as defined herein and where the substituents R, R1, R2, R3, R4, X, Y, Z, and m are as defined herein. These compounds are used in the treatment of bacterial infections, parasite infections, fungal infections, cancer, immunologic disorders, autoimmune disorders, neurodegenerative diseases and disorders, inflammatory disorders, or muscular dystrophy or for providing immunosuppression for transplanted organs or tissues.

  本发明的化合物由具有式（I）和式（I′）的下列化合物表示：其中取代基R、R1、R3 R4、R′、W、X、Y、Z、k和m如本文所定义，取代基R、R1、R2、R3、R4、X、Y、Z和m如本文所定义。这些化合物可用于治疗细菌感染、寄生虫感染、真菌感染、癌症、免疫性疾病、自身免疫性疾病、神经退行性疾病、炎症性疾病或肌肉萎缩症，或为移植器官或组织提供免疫抑制。
• PEPTIDOMIMETIC PROTEASOME INHIBITORS
  申请人：CORNELL UNIVERSITY

  公开号：US20200317729A1

  公开（公告）日：2020-10-08

  The compounds of the present invention are represented by the following compounds having Formula (I) and Formula (I′): where the substituents R, R 1 , R 3 R 4 , R′, W, X, Y, Z, k, and m are as defined herein and where the substituents R, R 1 , R 2 , R 3 , R 4 , X, Y, Z, and m are as defined herein. These compounds are used in the treatment of bacterial infections, parasite infections, fungal infections, cancer, immunologic disorders, autoimmune disorders, neurodegenerative diseases and disorders, inflammatory disorders, or muscular dystrophy or for providing immunosuppression for transplanted organs or tissues.