D-手性-纤维醇,2-O-b-D-吡喃半乳糖基-4-O-甲基- | 88840-01-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: D-手性-纤维醇,2-O-b-D-吡喃半乳糖基-4-O-甲基-
• 中文别名: 32-甲基-9,30-二氧杂-11,25-二氮杂五环[20.6.2.28,11.010,15.025,29]三十二碳-1-醇
• 英文名称: Xestospongin B
• 英文别名: 32-methyl-9,30-dioxa-11,25-diazapentacyclo[20.6.2.28,11.010,15.025,29]dotriacontan-1-ol
• CAS: 88840-01-1
• 化学式: C₂₉H₅₂N₂O₃
• 分子量: 476.7
• InChiKey: VJEURJNEIZLTJG-UHFFFAOYSA-N

物化性质

• 沸点：
  600.9±55.0 °C(Predicted)
• 密度：
  1.09±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  34
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  45.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• UNIMOLECULAR NANOPARTICLES FOR EFFICIENT DELIVERY OF THERAPEUTIC CATIONIC PEPTIDES
  申请人：Wisconsin Alumni Research Foundation

  公开号：US20180235897A1

  公开（公告）日：2018-08-23

  Provided herein are peptides comprising an amino acid sequence having at least about 85% sequence identity to RYRPRAPIIAVT (SEQ ID NO: 1). These cationic peptides inhibit PKM2 methylation and may be used in the treatment of breast cancer and other diseases or conditions in which PKM2 is overexpressed. Such PKM2 peptides may be delivered to cancer cells using pH sensitive unimolecular nanoparticles comprising anionic polymers.

  本文提供了一些肽，其中包含至少与RYRPRAPIIAVT (SEQ ID NO: 1)的氨基酸序列具有约85%的序列同源性。这些阳离子肽抑制PKM2甲基化，并可用于治疗乳腺癌和其他PKM2过度表达的疾病或病况。这些PKM2肽可以使用带有阴离子聚合物的pH敏感单分子纳米粒子输送到癌细胞中。
• Therapeutic cationic peptides and unimolecular nanoparticles for efficient delivery thereof
  申请人：Wisconsin Alumni Research Foundation

  公开号：US10660860B2

  公开（公告）日：2020-05-26

  Provided herein are peptides comprising an amino acid sequence having at least about 85% sequence identity to RYRPRAPIIAVT (SEQ ID NO: 1). These cationic peptides inhibit PKM2 methylation and may be used in the treatment of breast cancer and other diseases or conditions in which PKM2 is overexpressed. Such PKM2 peptides may be delivered to cancer cells using pH sensitive unimolecular nanoparticles comprising anionic polymers.

  本文提供的肽包含与 RYRPRAPIIAVT（SEQ ID NO: 1）至少具有约 85% 序列同一性的氨基酸序列。这些阳离子肽抑制 PKM2 甲基化，可用于治疗乳腺癌和 PKM2 过度表达的其他疾病或病症。这种 PKM2 肽可通过由阴离子聚合物组成的对 pH 值敏感的单分子纳米颗粒输送到癌细胞中。
• THERAPEUTIC CATIONIC PEPTIDES AND UNIMOLECULAR NANOPARTICLES FOR EFFICIENT DELIVERY THEREOF
  申请人：Wisconsin Alumni Research Foundation

  公开号：US20200276130A1

  公开（公告）日：2020-09-03

  Provided herein are peptides comprising an amino acid sequence having at least about 85% sequence identity to RYRPRAPIIAVT (SEQ ID NO: 1). These cationic peptides inhibit PKM2 methylation and may be used in the treatment of breast cancer and other diseases or conditions in which PKM2 is overexpressed. Such PKM2 peptides may be delivered to cancer cells using pH sensitive unimolecular nanoparticles comprising anionic polymers.