N-Furfuryl-1-piperidincarboxamid | 74729-69-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-Furfuryl-1-piperidincarboxamid
• 英文别名: Cambridge id 5792237；N-(furan-2-ylmethyl)piperidine-1-carboxamide
• CAS: 74729-69-4
• 化学式: C₁₁H₁₆N₂O₂
• mdl: MFCD00473906
• 分子量: 208.26
• InChiKey: VJABCZBUGDSODG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.545
• 拓扑面积：
  45.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  哌啶 、 光气 、 2-呋喃甲胺盐酸盐 生成 N-Furfuryl-1-piperidincarboxamid
  参考文献：
  名称：

  Ried, Walter; Christ, Rainer, Liebigs Annalen der Chemie, 1980, # 5, p. 693 - 698

  摘要：

  DOI：

文献信息

• Process for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
  申请人：Muller W. George

  公开号：US20080064876A1

  公开（公告）日：2008-03-13

  The present invention provides processes for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-diones which are useful, for example, for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF-α. The invention can provide cost-effective and efficient processes for the commercial production of substituted 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-diones, including, but not limited to, 4-[(N,N-dimethylhydrazono)methyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione, 4-aminomethyl-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione, and 4-[(acylamino)methyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-diones.

  本发明提供了制备取代的2-(2,6-二氧代哌啶-3-基)异吲哚-1,3-二酮的方法，该方法可用于预防或治疗与TNF-α水平或活性异常高相关的疾病或病况。该发明可以提供成本效益高且高效的方法，用于商业生产取代的2-(2,6-二氧代哌啶-3-基)异吲哚-1,3-二酮，包括但不限于4-[(N,N-二甲基肼)甲基]-2-(2,6-二氧代哌啶-3-基)异吲哚-1,3-二酮、4-氨甲基-2-(2,6-二氧代哌啶-3-基)异吲哚-1,3-二酮和4-[(酰胺基)甲基]-2-(2,6-二氧代哌啶-3-基)异吲哚-1,3-二酮。
• RIED W.; CHRIST R., LIEBIGS ANN. CHEM., 1980, NO 5, 693-698
  作者：RIED W.、 CHRIST R.

  DOI：——

  日期：——
• [EN] PROCESSES FOR THE PREPARATION OF SUBSTITUTED 2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLE-1,3-DIONE<br/>[FR] PROCÉDÉ DE PRÉPARATION DE 2-(2,6-DIOXOPIPÉRIDIN-3-YL)ISOINDOLE-1,3-DIONE SUBSTITUÉ
  申请人：CELGENE CORP

  公开号：WO2007136640A2

  公开（公告）日：2007-11-29

  [EN] The present invention provides processes for the preparation of substituted 2-(2,6- dioxopiperidin-3-yl)isoindole-l,3-diones which are useful, for example, for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF-a.The invention can provide cost-effective and efficient processes for the commercial production of substituted 2-(2,6-dioxopiperidin-3-yl)isoindole-l,3-diones, including, but not limited to, 4- [(N,N-dimethylhydrazono)methyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1.3-dione, 4-aminornethyl-2-(2,6-dioxopiperidin-3-yl)isoindole-l,3-dione, and 4-[(acylamino)methyl]-2- (2,6-dioxopiperidin-3-yl)isoindole-l,3-diones.
  [FR] La présente invention concerne des procédés de préparation de 2-(2,6- dioxopipéridin-3-yl)isoindole-1,3-dione substitués utiles, par exemple, pour prévenir ou traiter des maladies ou de conditions pathologiques associées à un niveau ou une activité anormalement élevé(e) de TNF-a. L'invention peut fournir des procédés économiques et efficaces de production commerciale de 2-(2,6-dioxopipéridin-3-yl)isoindole-1,3-diones substitués, comprenant, entre autres, 4- [(N,N-diméthylhydrazono)méthyl]-2-(2,6-dioxopipéridin-3-yl)isoindole-1.3-dione, 4-aminométhyl-2-(2,6-dioxopipéridin-3-yl)isoindole-1,3-dione, et 4-[(acylamino)méthyl]-2- (2,6-dioxopipéridin-3-yl)isoindole-1,3-diones.