8-(1-benzofuran-2-yl)-N-(1-benzylpiperidin-4-yl)-1,6-naphthyridine-2-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 8-(1-benzofuran-2-yl)-N-(1-benzylpiperidin-4-yl)-1,6-naphthyridine-2-carboxamide
• 化学式: C₂₉H₂₆N₄O₂
• 分子量: 462.5
• InChiKey: MGMDGVGMADVIAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  35
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  71.3
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• 2,8-Disubstituted naphthyridine derivatives
  申请人：Hanson J. Gunnar

  公开号：US20060030584A1

  公开（公告）日：2006-02-09

  Disclosed are compounds of formula A: and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 2 ′, R 3 , R 21 , A 1 , A 2 , X, and Z are as defined herein. Compounds of formula A are useful in the treatment of diseases and/or conditions related to cell differentiation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

  揭示了公式A的化合物及其药学上可接受的盐，其中R1、R2、R2′、R3、R21、A1、A2、X和Z如本文所定义。公式A的化合物在治疗与细胞分化相关的疾病和/或症状方面具有用途，如癌症、炎症、关节炎、血管生成等。还披露了包含本发明化合物的药物组合物和使用这些化合物治疗上述症状的方法。
• 2, 8-disubstituted Naphthyridine Derivatives
  申请人：Hanson J. Gunnar

  公开号：US20080032991A1

  公开（公告）日：2008-02-07

  Disclosed are compounds of formula A: and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 2 ′, R 3 , R 21 , A 1 , A 2 , X, and Z are as defined herein. Compounds of formula A are useful in the treatment of diseases and/or conditions related to cell differentiation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

  本发明揭示了A式化合物及其药学上可接受的盐，其中R1、R2、R2′、R3、R21、A1、A2、X和Z的定义如本文所述。A式化合物在治疗与细胞分化相关的疾病和/或病况（如癌症、炎症、关节炎、血管生成等）方面具有用途。此外，本发明还揭示了包含所述化合物的制药组合物和使用这些化合物治疗上述病况的方法。
• 2, 8-DISUBSTITUTED NAPHTHYRIDINE DERIVATIVES
  申请人：Serenex, Inc.

  公开号：EP1773834A2

  公开（公告）日：2007-04-18
• US7282506B2
  申请人：——

  公开号：US7282506B2

  公开（公告）日：2007-10-16
• [EN] 2, 8-DISUBSTITUTED NAPHTHYRIDINE DERIVATIVES<br/>[FR] DERIVES DE NAPHTHYRIDINE 2, 8-DISUBSTITUES
  申请人：SERENEX INC

  公开号：WO2006017672A2

  公开（公告）日：2006-02-16

  Disclosed are compounds of formula (A) and pharmaceutically acceptable salts thereof, wherein R1, R2, R2' , R3, R21, A1, A2, X, and Z are defined herein. Compounds of formula (A) are useful in the treatment of diseases and/or conditions related to cell differentiation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.