7-(Furan-2-yl)-5-oxospiro[1,3-dihydro-[1,2,4]triazolo[1,5-a]pyridine-2,1'-cyclopentane]-6,8-dicarbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三唑并吡啶类
• 英文名称: 7-(Furan-2-yl)-5-oxospiro[1,3-dihydro-[1,2,4]triazolo[1,5-a]pyridine-2,1'-cyclopentane]-6,8-dicarbonitrile
• 化学式: C₁₆H₁₃N₅O₂
• 分子量: 307.312
• InChiKey: ITUNORKVTPMRRH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (2-呋喃亚甲基)丙二腈 、 cyanoacetic acid cyclopentylidene hydrazide 在 三乙胺 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以78%的产率得到7-(Furan-2-yl)-5-oxospiro[1,3-dihydro-[1,2,4]triazolo[1,5-a]pyridine-2,1'-cyclopentane]-6,8-dicarbonitrile
  参考文献：
  名称：

  Hussein; Sherif; Atalla, Polish Journal of Chemistry, 1996, vol. 70, # 7, p. 872 - 879

  摘要：

  DOI：

文献信息

• A new synthesis for 1,2,4-triazolo[1,5-a]-pyridines and 1,2,4-triazolo[1,5-a]isoquinolines
  作者：A. M. Hussein、S. M. Sherif、A. A. Atalla

  DOI：10.1007/bf00844690

  日期：1996.11

  Condensation of cyano acid hydrazide 1 with cyclopentanone in refluxing ethanolic piperidine yields hydrazone 2. With mixtures of aliphatic aldehydes and different active methylene reagents, 2 reacts to 1,2,4-triazolo[1,5-a]pyridines (8a-f). Compound 2 also reacts with arylidenes 9a-g to give triazolopyridines 10a-g. Reaction of 2 with aromatic aldehydes affords compounds 13a-c. Diazotation of 2 with aryldiazonium chloride in ethanol at 0 degrees C leads to the azo adducts 15a-d. The thieno-1,2,4-triazolopyridine 16 is obtained by reaction of 8a with elementary sulfur. 16 undergoes cycloaddition with omega-nitrostyrene, maleic anhydride, N-arylmalemide, and acrylonitrile yielding the isoquinolines 21-24. All new compounds have been characterized by their IR, H-1 NMR, and mass spectra.
• Novel pharmaceutical and diagnostic compositions for use in the treatment and diagnosis of neurodegenerative diseases or amyloid diseases
  申请人：Wanker Erich

  公开号：US20090117040A1

  公开（公告）日：2009-05-07

  The present invention relates to pharmaceutical and diagnostic compositions as well as to the use of the active substances contained therein for preparing a pharmaceutical or a diagnostic composition for the treatment or diagnosis of neurodegenerative disorders or amyloid diseases.
• US8710088B2
  申请人：——

  公开号：US8710088B2

  公开（公告）日：2014-04-29
• Hussein; Sherif; Atalla, Polish Journal of Chemistry, 1996, vol. 70, # 7, p. 872 - 879
  作者：Hussein、Sherif、Atalla

  DOI：——

  日期：——