(3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]-3-[[4-(beta-D-glucopyranosyloxy)-3-methoxyphenyl]methyl]dihydro-2(3H)-furanone

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 木脂素苷
• 英文名称: (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]-3-[[4-(beta-D-glucopyranosyloxy)-3-methoxyphenyl]methyl]dihydro-2(3H)-furanone
• 英文别名: (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[[3-methoxy-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]methyl]oxolan-2-one
• 化学式: C₂₇H₃₄O₁₁
• 分子量: 534.6
• InChiKey: XOJVHLIYNSOZOO-RVDKUWPISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  38
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  153
• 氢给体数：
  4
• 氢受体数：
  11

文献信息

• Cosmetic compositions decreasing GM-CSF release induced by nickel salts
  申请人：Cognis IP Management GmbH

  公开号：EP1902755A1

  公开（公告）日：2008-03-26

  Suggested are cosmetic compositions comprising: (a) a working amount of at least one agent that decreases the GMCSF release induced by nickel salt and (b) a cosmetically acceptable excipient.

  建议的化妆品组合物包括 (a) 至少一种能减少镍盐诱导的 GMCSF 释放的制剂的工作量，以及 (b) 化妆品可接受的赋形剂。
• Composition and method for treating skin by administering silybin and piperine/terahydropiperine
  申请人：Cognis IP Management GmbH

  公开号：EP1902756A1

  公开（公告）日：2008-03-26

  Suggested are cosmetic compositions comprising in a cosmetically acceptable excipient (a) silybin and (b) piperine and/or tetrahydropiperine. The compositions are suitable for preventing and/or soothing dry skin or reactive skin against external stresses.

  建议的化妆品组合物含有化妆品可接受赋形剂 (a) 水飞蓟宾和 (b) 胡椒碱和/或四氢哌啶。这些复合物适用于预防和/或舒缓皮肤干燥或皮肤对外界压力的反应。
• Process for using phytochemicals and sugar acids to create one or more engineered media for use in a water purification filter
  申请人：Saha Anuj K

  公开号：US10059605B1

  公开（公告）日：2018-08-28

  The process for creating one or more engineered media for use in a water purification filter is a passive multi-stage multi-media filter for use in water purification. The process for creating one or more engineered media for use in a water purification filter removes harmful contaminants from a water stream including, but not limited to, toxic heavy metals and metalloids, pharmaceutical residues, micro-toxins, endocrine disrupters, chlorinated and other halogenated solvents, fluoride, nitrate, and naturally occurring radioactive contaminants. The process for creating one or more engineered media for use in a water purification filter maintains concentrations of phytochemicals that provide health benefits. Water processed through the process for creating one or more engineered media for use in a water purification filter meets United States, European Union and World Health Organization standards for safe drinking water.

  制造用于水净化过滤器的一种或多种工程介质的工艺是一种用于水净化的无源多级多介质过滤器。制造用于水净化过滤器的一种或多种工程介质的工艺可去除水流中的有害污染物，包括但不限于有毒重金属和类金属、药物残留物、微毒物、内分泌干扰物、氯化溶剂和其他卤化溶剂、氟化物、硝酸盐和天然放射性污染物。制造用于净水过滤器的一种或多种工程介质的工艺可以保持植物化学物质的浓度，从而为健康带来益处。通过制造用于净水过滤器的一种或多种工程介质的工艺处理的水符合美国、欧盟和世界卫生组织的安全饮用水标准。
• Cosmetic Compositions
  申请人：Danoux Louis

  公开号：US20090298783A1

  公开（公告）日：2009-12-03

  Disclosed is a method for preventing and/or soothing dry or sensitive skin against external stresses, comprising contacting the skin with a composition including an agent that decreases the release of granulocyte-macrophage colony-stimulating factor (GMCSF) from keratinocytes in the skin, wherein under conditions of external stress, dry or sensitive skin is soothed and/or prevented. Agents that decrease the release of GMCSF include silybin, piperine, tetrahydropiperine, nortrachelogenine, rhapontin, arctiin, artigenin and mixtures thereof. Also disclosed is a method of identifying an agent that decreases the level of GMCSF released from keratinocytes.